Touganou develops a crush on Suzuna in this episode.
American Football Clinic Trivia Q & A of the episode:
Q: How do you start the game?
A: Kickoff. The ball is kicked off from the 35-yard line. YA-HA!
Suzuna (in a Devil Bats cheerleader outfit): "Go, go, let's go! Go, go, Devils! Fly, fly, Bats! Run, run, Bats! Come out, come out, 21! Eyeshield 21! 21, come out now! Eyeshield... (does a back flip) 21!
After this episode first aired, there was a special segment called "Anezaki Mamori's Complete Guide to American Football." It had Mamori, Sena, and Monta's voices talking about football's history, different leagues, Japanese players, tournaments, its impact on America and Japan, and its special events (including the Christmas Bowl). It later goes on to say that the Christmas Bowl of 2005 will be on December 25 in Ajinomoto Stadium. There is also a little bit where Sena almost gives away the fact that he is Eyeshield to Mamori.
This episode first aired as the first half of a 1-hour special block.
The real reason as to why Suzuna took the job to discover Eyeshield 21's true identity is that she is looking for her missing older brother who disappeared while trying to become a star player in American football. So, Suzuna thought that Eyeshield was actually her brother.
Suzuna goes to America to search for her brother.
Taki Suzuna makes her debut in this episode.
At one point, Suzuna says "Pakkyun," which is a Japanese sound effect for shooting something. Touganou plays off of that by saying "Kyunn," a Japanese onomatapoeia for a heartbeat.