This is a TV Show based on the manga. It follows the manga storyline very closely, with only a few added adjustments.
Sena is a small first-year. Throughout his life he's been a gopher, running back and forth doing errands for bullies. But now that's changed. He`s gotten so fast, that he can run the 40-yard dash in 4.2 seconds, while being chased by the ferocious dog Cerberus, the football team's pet.
Sena's now been accepted to the school football team as the new runningback, undercover as EyeShield 21, to avoid being hassled. He gets quite nervous before a game, but then learns he outrun anyone, well almost anyone.
I shan`t tell you anymore, or I shall spoil it all. But really if you want to find out what happens, read the manga.