I personally don't want to see the show try anything at all... I don't think I can careless about the show now. I know I commented earlier about them trying to take on MLP or LoK, but that was out of the idea of how much can FAIL at making fun of shows clearly better than them in everyway... what else can we expect from the show now?
Make a parody of a movie/tv show that hasn't been done to death online?
Brian getting a new date that is clearly wrong for him (or wrong for her) or being a "hero" in an episode about politics or religion?
Meg get some act of kindness from her family in one episode, only to be the butt in other episodes (sometimes even WITHIN said episodes that have be treated like a human being)?
Have Stewie be a genius in episodes that need him to be, and not the "evil genius" we fell in love with?
Peter being a striaght out heartless selfish jerk to his family and friends while he goes on a drunken antic that he was inspired by tv or something, while we don't care for it because he use to do them for his family, but now it's just for himself?
Having a joke about how cheap jews are as protrayed by Mort Goldman?
Having something WE wanted to happen, only to have in one or 2 episodes and never again?
To miss joke or stories just because the writers/directors are lazy SOBs?
What can Family Guy do that can save it from ALL OF THIS?