The upstairs layout changes when Francis catches Chris in the bathroom the second time.
The sign outside of the banquet hall reads Now Free of that Urine Smell.
The airline that the Pope travels on is Blessed Virgin Airways.
The Pope's road crew wear jackets that say Pope-apalooza.
The sign on Peter and Lois's car after their wedding says Just Married...To A Protestant Whore.
We are introduced to Peter's father and mother in this episode.
The scene where Peter's at church was also in the original pilot episode.
Patrick Warburton, who voices Joe Swanson on the show, appears in this episode, voicing Superman (whom he also voiced on a commercial for American Express with Jerry Seinfeld).
Peter: Dad, my God, are you okay?
(Francis slaps Peter in the face)
Francis: Don't be using the Lord's name in vain.
Peter: He's okay, thank God.
(Francis slaps Peter again)
Pope: Are you sure this is Boston?
Peter: Oh, yeah. (Points to a barn) Look, there's Harvard.
Pope: That's just a barn.
Peter: Ooh, I see someone went to Yale!
(After returning from church)
Chris: I didn't know there was a five a.m. mass. I didn't even know there was a five a.m. What else haven't you told me?!
Stewie: Why does the man drop his club before he runs? I would bring it with me!
The Pope's Emcee: Hello Boston, are you ready to humblllleeee yourself before God? (Pauses) What, have you all taken a vow of silence? Come on!
Pope: It's as you said before Peter, I am a'da freaking Pope!
Lois: Kids, your grandfather's ears are not gross and they are certainly not an enchanted forest.
Stewie: (reading the Bible) My, my. What a thumping good read! Lions eating Christians, people nailing each other to two-by-fours. I say, you won't find that in Winnie the Pooh.
Francis: You're a good woman, Lois. Perhaps you won't burn in hell after all. Maybe you'll just go to purgatory with all the un-baptized babies.
Peter: There you go, Lois, you love kids.
Lois: He just got up and left? Where would he go?
Peter: I don't know. I just asked him to buy me some peanuts and crackerjacks.
Brian: I don't care if he ever comes back.
Brian: I wasn't being cute, I really hope he's dead.
Peter: We all love the bible in this house.
Francis: Really? What's your favourite book of the bible.
Peter: Umm... the one where Jesus swallows the puzzle piece, and the man in a big yellow hat has to take him to the hospital.
Peter: My dad worked at that factory for sixty years. That's almost eighty years.
Family Guy was pulled after this episode aired due to low ratings and returned in March to finish airing the second season.
The doll Peter assembles says, "Any of you kids want to see a dead body?" On the captions on the Adult Swim airings, it says, "Any of you kids want to score some pot?"
Cool Hand Luke
The scene involving the chain gang working on the street with one of the men saying "I'm takin' it off here, boss" is an allusion to Cool Hand Luke.
Peter: To the Popemobile!
When Peter and the Pope race in the Popemobile, we see a scene transition very similar to the ones found in the TV series BATMAN (1966).
Peter: The one where the Jesus swallows the puzzle piece, and the man in the yellow hat has to take him to the hospital.
This is a reference to "Curious George". George was a chimp who'd get into all kinds of trouble, and his owner, the man in the yellow hat, would always bail him out.
Francis: Now give me a hug before I give you a knuckle 'samich'
Sanford and Son was a popular show that ran in the 70s about a man and his son that ran a salvage company.
The Dick Van Dyke Show
Francis: Laura burns the roast, and God kills her for parading her bum around in those pants.
The Dick Van Dyke Show was a hugely successful sitcom in the 60s starring Dick Van Dyke and Mary Tyler Moore. (who played Laura) Laura frequently wore tight fitting pants... it was the 60s after all. The show spawned a whopping SEVEN spin offs including Rhoda, The Mary Tyler Moore Show and others. Mary Tyler Moore is seen in history as being a major role model in the Women's Liberation Movement.