While gathered together on Frasier's balcony, Martin, Frasier, and Niles are talking. Frasier mentions "It's just an hour by plane" (between San Francisco and Seattle). Most commercial flights run in the two hour to two and a half hour range between those two cities.
In "Don't Go Breaking My Heart (3)" in the flash-forward to Niles' and Daphne's second child's birth, Niles is holding a girl. In this episode, Daphne gave birth to a boy.
Roz: You've always been just like a brother to me. Which is weird, I know, because we slept together and...
Ronee: Well, Marty, we'd better get going. I've got a crazy morning.
Roz: Me, too. I've got a 7:30 meeting, and then I've got to fire someone.
Roz: Whoever scheduled the 7:30 meeting.
Bebe: Frasier! It's done. When destiny calls, Bebe calls back and screws destiny to the wall.
Niles: I'll miss the coffees.
(Frasier's final farewell to his listeners on KACL after reading Ulysses.)
Frasier: I've been thinking about that poem a lot lately. And I think what it says is that, while it's tempting to play it safe, the more we're willing to risk, the more alive we are. In the end, what we regret most are the chances we never took. And I hope that explains a little this journey on which I'm about to embark. I have loved every minute with my KACL family and all of you. For eleven years you have heard me say, 'I'm listening.' Well, you were listening too. And for that I am eternally grateful. Goodnight, Seattle.
(Last line of the series.)
Frasier: Wish me luck.
Frasier: When I go through that Golden Gate, I'll be smiling.
Martin: Golden Gate?
Frasier: Yes, in San Francisco. I'm moving to San Francisco. Now I know this is a hard time to accept, so let it all out.
(Everyone laughs, after thinking that Frasier was dying)
In the scene at Cafe Nervosa when Roz reveals that she is the new station manager, writer/producers Bob Daily, Lori Kirkland Baker, Jon Sherman and Heide Perlman can be seen as coffee-sipping patrons in the background.
In the scene at the vets, the cat owner is played by Jeff Greenberg who was the shows casting director. His cat was called Saladin named after writer Saladin K Patterson.
In the scene where Frasier gives his farewell speech on KACL, behind him through the glass can be seen creators David Lee and Peter Casey as well as writers Joe Keenan and Christopher Lloyd and editor Ron Volk
With a final total of ten appearances, this episode earns Harriet Sansom Harris the "bronze medal" for third place among recurring characters, placing her behind Luck Hari (11) and Edward Hibbert (12).
At the 2004 Emmy Awards, Kelsey Grammer won the Emmy for Outstanding Lead Actor in a Comedy Series for his performance in the episode "The Doctor is Out". In addition David Hyde Pierce won the Emmy for Outstanding Supporting Actor in a Comedy Series for his performances in the episodes "No Sex Please, We're Skittish" and "Goodnight, Seattle (2)". The show was also nominated for Outstanding Casting for a Comedy Series.
This one-hour Series Finale episode won the 2004 Emmy for Outstanding Editing in a Multi-Camera Series. Also Christopher Lloyd & Joe Kennan were nominated for a 2004 Emmy for Outstanding Writing in a Comedy Series for their work on this one-hour Series Finale episode.
A "Dr. Hanning" leaves a message on Frasier's machine, a reference to Rob Hanning, a former Writer and Executive Producer on the show.
Kelsey Grammer's 20 year run as Frasier Crane is the longest any actor had played a single character in a non-daytime drama.
This is Arleen Sorkin's first appearance on the show as a character, although she provides the original reading for most of the callers to Frasier's radio show during taping. Her audio is then replaced by the celebrity guest's recording. Despite being a rather celebrated voice artist, she has never portrayed an actual caller to the show. She is also married to "Frasier" Executive Producer Christoper Lloyd.
Niles and Daphne's baby is called David Crane. There is a real person called David Crane who wrote for "The Powers That Be", which was David Hyde Pierce's previous show before "Frasier". David Crane was also the co-creator and executive producer of "Friends", which in a way is ironic!
Cleto Augusto played a deliveryman in the first ever "Frasier" episode, and now plays a moving man in the last ever "Frasier" episode. Besides the regulars, he is the only person to appear in both the first and last episodes.
Originally aired as an hour long episode.
Frasier: "... To strive, to seek, to find and not to yield."
Frasier's farewell to Seattle are the last nine lines of Lord Alfred Tennyson's poem "Ulysses."