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Eleven of the twelve members of a focus group think The Frasier Crane Show is perfect. Frasier obsesses about the one man who disagrees, the owner of a newspaper stand, and begins to stalk him.
Frasier's old love, Diane Chambers, comes to Seattle for the grand opening of her play about the "losers" at Cheers and their hopeless obsession with "Mary Anne."
Realising that he doesn't have any friends other than Niles, Frasier appeals to his listeners hoping to make a new friend. Responding to a fax, Frasier agrees to meet a man for coffee - and soon discovers that they have nothing in common.
Frederick's Christmas visit to Seattle spells headaches for Frasier when he tries to get his son the proper gift. Meanwhile, Maris freezes Niles' bank accounts.
A huge fight between Niles and Maris prompts Maris to threaten divorce, while Martin and Frasier urge Niles not to crawl back to her.
In a psychiatrist's office, Frasier and Niles each recount their disastrous attempt to go into practice together.