As Niles is [finally] explaining his true feelings to Daphne, Donny enters the room and asks Niles: What's the difference between a blister and a boil?! Maybe he was preoccupied, but the advice that Niles giving Donny is not really sound, medically speaking.
Niles should be able to tell the difference between a blister or a boil. These are pretty common skin conditions and certainly would have been a part of his medical training.
A single skin boil is an infection , which can be mild (and heal on its own) or it could be a sign of something more serious (i.e. diabetes, weaken immune system or a staph infection). The fact that it seems to be causing Donny pain, would suggest that it is on the more serious side.
Medical treatment involves minor surgery, incision and drainage, and possibly antibiotics. Granted, a wedding is probably not the best way to perform this surgery, but it is something that would need to be addressed sooner rather then later.
"Lukewarm" water is not even a temporary solution for a boil. Warm water, not boiling but hotter then lukewarm, may help with some of the pain and it may help the boil bust ("come to a head").
Heck, getting a sharp pin or knife, sterilizing it with some alcohol, and using it to pop the boil would be better advice then "lukewarm" water. This method may leave a scar and cause additional complications, but it would probably alleviate the pain.
There are a couple people missing from the wedding guests without explanation. Daphne's father, for one (who'll give her away?). Also, Frasier's date (the reason Roz had to enlist Simon as her escort).
When the band is playing "They Can't Take That Away From Me," the song changes chords and notes, but the pianist's hands do not move accordingly.
While Niles & Daphne are kissing on the balcony, there is a camera change. When this happens Niles hands change positions.
Martin mentions at the bar that they are going to stop making Ballantine. In truth, Ballantine was bought by the Pabst brewing company and is still available today, though no longer advertised. It is thought that its decline in popularity was due to the increased sales of imported and domestic light beers, but it still has a small, but loyal following to this day.
The entire Moon clan is under the misconception that Daphne is pregnant. Her mother finds it neither surprising nor troublesome. In "Mother Load" (Season Nine), however, Daphne goes out of her way to keep alive her mother's illusion that she is still a virgin.
Two endings were originally shot for this episode, one in which Daphne comes for Niles and one in which she stays with Donny. The studio audience then got to choose their favorite.
(Daphne and Niles are alone in a hotel room. Simon walks in to grab some more liquor before last call)
Simon: You're not having a last call of your own, are you, sis?
Niles: I must be in love. It doesn't even bother me that you come with them!
At the 2000 Emmy Awards, "Frasier" received a nomination for Outstanding Comedy Series. In addition Kelsey Grammer was nominated for Outstanding Lead Actor in a Comedy Series, for his performance in the episode "Radio Wars", and David Hyde Pierce was nominated for Outstanding Supporting Actor in a Comedy Series.
First appearance of Gertrude Moon, Daphne's mum, played by Millicent Martin.
Originally broadcast as part of a one-hour episode.