This episode seems to indicate that when Frasier first returned to Seattle he retained much of his old Boston self - proudly drinking plain black coffee (and scoffing at Niles coffee order) and having a beer with his father (he typically drank beer at Cheers). At some point between his return and the first episode of season one (three months later), Frasier's personality changes considerably.
Martin tells Frasier that he was listening to the Mariners game, fell asleep, and when he woke up, Frasier's show was on. It's unlikely that KACL would be covering Mariner's games since it's a talk station and not a sports station.
In the scene that takes place in Martin's apartment you can see a Frank Sinatra album on the shelf behind Martin's recliner. In the episode "Martin Does it His Way" we find out that Martin is a huge Frank Sinatra fan.
This episode originally aired on the exact date of what would have been the third anniversary of Frasier's first radio broadcast as given in the storyline - May 21, 1993.
A bit of an ironic nod to "My Coffee with Niles" as, during the flashback, Frasier first visits Cafe Nervosa and is aghast at Niles's incredibly nit-picky coffee order. Frasier says that a simple cup of good old American coffee is good enough for him. In "My Coffee" Frasier never gets his latte that features many special requests and conditions.
During the flashbacks to 1993, all the characters have their 1996 appearances!
(Frasier has run into Niles at the Café Nervosa following his very first show)
Frasier: Niles, aren't you going to join me?
Niles: Oh, well... I would, but... I have a routine. I come in every day, order coffee, and spend some quality time -- with myself. You understand.
Frasier: (incredulous) Niles, I've seen you once in the last two years!
Niles: (after a long, confused pause) Oh, that is your point.
Daphne: Oh, Dr Crane, why is it so easy to love our families, yet so hard to like them?
Fraiser: Well, Daphne, that's just one of those little questions that makes life so rich. And psychiatrists even richer.
Frasier: In the last week I've uprooted myself from my home of fifteen years, moved all the way across the country away from everything I care about, and plunged myself into a frightening new career. The first few nerve-wracking moments, I walk in here and find my producer lobbying to get herself transferred to another show. Abe Lincoln had a brighter future when he picked up his tickets at the box office!
Frasier: (to Niles) You know, I'd forgotten what a weird little person you are.
At the 1996 Emmy Awards, Frasier won its third consecutive award for Outstanding Comedy Series. Kelsey Grammer received a nomination for Outstanding Lead Actor in a Comedy Series his performance in the episode "You Can Go Home Again". In addition David Hyde Pierce received a nomination for Outstanding Supporting Actor in a Comedy Series. The show was also nominated for Outstanding Casting for a Series.
The final part of the episode presents all the guest stars that lended their voices for the people that called Frasier at his radio program.
Frasier: Fasten your seatbelt, Eddie, it's going to be a bumpy ride.
Frasier is quoting the famous line by Margo (Bette Davis) in the 1950 film All About Eve.