If you've never been in Fry's shoes in this episode, then count yourself to be one lucky son of a gun. I've seen this episode many times and each time it proves meaningful since I find myself in some random heartbreak every few months.
It never ceases to amaze me that Futurama can be completely absurd with the Harlem Globetrotters, be absolutely hilarious, and prove to be one of the most touching shows on television.
Catch this episode for some real life truly touching pain in a comedic setting. You don't see that in Family Guy.