George: You don't go to war without a general! You don't play football without a quarterback! You don't have a wolf pack without... what's the head wolf called?
Ernie: The lone wolf?
George: The lone wolf can't be the leader, he's alone!
Ernie: Maybe they're following him but he doesn't know it.
George: Do you want to go to the factory or do you want to talk about wolves?
Ernie: I wanna go to the factory, but can we talk about wolves on the way?
Benny: What did Vega want?
George: The company's staying here and I'm going to be manager.
Benny: Either he's a big gambler or he's dumb.
George: Maybe he's both, you don't know him!
Mr. Vega: You've either got a lot of guts, or you're an idiot.
George: Maybe I'm both, you don't know me!
Mr. Vega: Here you make $16 an hour, do you know how much the workers get paid in Mexico?
George: Yeah, $2.75 an hour. But I also know that a lot of your companies are right here in America and bad publicity is going to cost you a lot of money.
George: Ernie, if you're here to tell me how much you're going to miss me, don't say anything more.
Ernie: I'm not here about about that. Geez, it's not always about you, conceited!
(George and Angie are talking about moving)
Angie: We fell in love here. We conceived our kids here.
George: We still have that Angie. We're taking the couch.
George: They are going to take our jobs and give 'em to Mexicans...This is America, we got our own Mexicans!
George Lopez, Constance Marie, Belita Moreno, Luis Armand Garcia, and Valente Rodriguez were the only characters to both appear in the Pilot and Series finale.