In the Episode "Long Time No See", Benny has a flashback in which she mentions that her mother took care of George while she and Manny were at work. This clashes with information received in the episode "George Testi-Lies for Benny", where we find out that Benny's mother completely disowned her after she got pregnant with George.
"George Lopez" and "Freddie" are in the same universe. However, Jacqueline Obradors's characters in both shows are different.
We learn that George's middle name is Edward, just like the real life George Lopez.
Watch closely: When Benny is talking about how she was made fun of in high school, the exclamation point on the window is written with a heart at the bottom. Moments later, when she's cleaning the window, the exclamation point is written normally, no heart.
George, Erine, and Angie all went to the same high school together and George and Erine both had long hair.
There is an alternate ending to this episode that is on the DVD release.
We learned how George and Angie got together
George's favorite band is Black Sabbath
George Lopez is the one who discovered Emiliano Diez an was his idea to bring him into the show as his father in-law which wasn't even written in the script yet.
We learn that George was born in 1965
We learn that both Amy and her daughter Kimmy have a depth deception problem.
We learn Amy has a daughter named Kimmy.
This is the second time we see Amy (Sandra Bullock)since the episode "Happy Birthdays", which was episode 3.
We learn that George has a crush on actress Selma Hayek.
When Max starts talking to his dad when he comes down to do his homework his pencil keeps moving in shots.
Oops! Even though in "Prototype", George says its a bad idea to wear a tie in an Airplane Parts factory, he does so in this episode. In fact, he even forgets to take it off when he gets on his old machine!!
We meet Ernie's mom in this episode. Despite jokes and references made in later episodes, she does not appear to be overweight.
Ernie's full name is revealed: Ernesto Cardenas.