Dan and Blair have a different kind of chemistry than Blair and Chuck. With Blair and Chuck it was all passion and lust-- something that started when they were younger. With Blair and Dan, it's trust and comfort, and I'm glad the writers are pursuing this love story with them. I don't necessarily think they should end up together, but the viewers and Blair's character need to at least try it out and give the relationship a chance. It wouldn't be fair to have all this buildup for Dair and then just leave us hanging.
I like the Lola/Charlie storyline and I'm interested in finding out where the writers are going with it. Obviously, this show is completely unrealistic and not plausible for regular people, but that doesn't mean it's not interesting. However, I'm curious as to how much longer this show can last; I don't think I'll be watching after this season is over.