Derek: Meredith. You know I was kidding this morning. (smiles) I mean you can tell me about this horrible thing. Come on, you can talk to me.
Meredith: As a friend?
Derek: As a friend.
Meredith: There's a line between friends and not-friends and if I tell you this, if I tell you this whole horrible thing then you have to react as my friend. Not my not-friend.
Derek: I can do that. Alright, tell me what's wrong, I'll tell you how to fix it.
Meredith: Okay, are you ready?
Derek: I'm ready.
Meredith (groans): I slept with George. (Derek loses his smile) And it was a horrible mistake and now everything has changed and I don't know how to repair it. I don't even know where to start, but I just know that I have to and... Say something friendly.
Derek: You tell him that. You find George and you apologize.
Meredith: That's what everyone's saying, but he won't listen.
Derek: Tell him again. You tell him you're sorry. Just tell him again and again and again until he listens.
Meredith: How do I do that?
Derek: You do what I do. Use the elevator.