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The impact of Derek's death is felt by Meredith and her coworkers. Meanwhile, April makes a surprising decision, which leaves Jackson baffled; and Bailey and Ben disagree about their future.
Derek sees a ghastly accident and jumps into action to help the wounded.
A small plane crash occurs, triggering bad memories for Meredith and Arizona as injured victims are brought to the hospital. Meanwhile, tension between Owen and Amelia creates an awkward work environment for Stephanie.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheating ways.
A group of children visit the hospital on a field trip and observe two injured cops rushed into the emergency room. Meanwhile, Stephanie develops a crush on one of the chaperones; and Amelia's forced confront her feelings about Owen.
Rattled by recent events, Meredith tries to decide what to do about Derek; Owen is stunned when his mother is admitted to the hospital.
A man with Alzheimer's crashes into a pregnant woman; Meredith worries about Derek cheating on her and the date of their marriage.
An earthquake leaves Maggie trapped in an elevator and threatens Meredith's streak of successful surgeries; Owen gives medical advice over the phone.
The moment of truth has arrived. Amelia begins the daunting surgery to remove Dr. Herman's tumor. Meanwhile, Arizona takes the lead on a case that means a lot to Dr. Bailey.
The hospital doctors become fascinated with Dr. Herman's case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of cases they are trying to complete before the big surgery. Meanwhile, Bailey brings them a case of a pregnant woman who is close to her heart.moreless
Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben's brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.
April and Jackson face a tough decision concerning their unborn baby. Elsewhere, Catherine encounters Richard at the hospital; Meredith searches for a babysitter so she can visit Derek; and Amelia tries a tough-love approach while working with Stephanie.
April stays positive as tests are run on her baby; Dr. Herman plans a crash course in fetal surgery; Callie and Owen encourage each other to return to the dating scene; Bailey, Meredith and Maggie try to learn more about a patient's tumor.
Meredith keeps herself busy while Derek prepares for his move; Jackson and April get difficult news; Arizona and Amelia talk about how best to approach Dr. Herman.
Pierce and Grey disagree with Derek about the best way to approach a patient's case, which lead the couple to a very big argument. Meanwhile Callie feels responsible for one of her veterans when he is pushed too far and a doctor's routine procedure shows devastating results.
Amelia's past addictions don't stay hidden and result in trouble for her at work. Meanwhile, Jo performs her first solo surgery; Arizona must make a tough call when Dr. Herman is away; and a couple who were caught in a fire arrive at the ER.
Owen bonds with a patient who may have been in the military. Meanwhile, April's mom visits her and Jackson; Bailey takes a closer look at her own health; Derek arranges a family meal; and Dr. Herman has shocking news for Arizona.
Callie and Arizona examine their marital problems and what's contributed to them. Meanwhile, Callie devotes herself to the veterans' project; Arizona strives to impress Dr. Herman; and Richard seeks guidance from Bailey.
Secrets from Ellis Grey's past come to light. Maggie makes a shock announcement and Callie continues to work on the Veteran's Project.
Alex and Meredith's friendship ignites jealousy in Jo. Meanwhile, Maggie continues to open up to Richard; Owen wants Callie to use her robotic-limb lab to assist veterans; and Alex and Bailey prepare to face the hospital board.
Maggie tries to prove her worth and befriend others at the hospital, but she lands in some bad predicaments. Meanwhile, Richard doesn't want to disclose his secret; and the doctors assist a dying woman whose daughter won't let her go.
In the 11th-season opener, Meredith finds her life in chaos both at work and at home. Meanwhile, Callie and Arizona make a choice regarding surrogacy; Amelia discovers a secret; and Bailey and Alex battle for Cristina's seat on the board.