Grey's Anatomy Season 8 Episode 8

Derek: A man just booked a flight from Witchta. You want to tell him no, I'll give you his number and you can tell him yourself.
Owen: I'm not worried about the hospital's mortality rates, Derek. I'm worried about you. You've had a lot of losses this year and I'm concerned that you're lining yourself up for more.
Derek: You're worried about my reputation.
Owen: Well, there is--
Derek: I don't have a reputation anymore. I was gonna be the guy who cured Alzheimer's, now I'm blacklisted by the FDA so, I don't have to worry about that anymore. I get to choose what I worry about. And I choose them. I feel that I can change their story. I owe it to them to at least try.
Owen: That's-- That's pretty damn arrogant, don't you think?
Derek: Well, I have a reputation for arrogance.