Lexie plans a surprise for Alex. She was waiting for him on his bed, naked. The surprise is ruined when Derek walks in on her, followed by Meredith. Meredith warns Lexie about Alex's ways and that he will end up hurting her. Lexie tells Meredith that their relationship is strictly physical, but Meredith doesn't believe her; she knows that Lexis is not capable of a casual relationship.
Cristina has a great surgery with Teddy and tells Owen about it. Owen is surprised that they are actually hitting things off. Cristina encourages him to become her friend as well. Owen invites Teddy out for a beer but she already has plans for a girl's night out, which was organized by Arizona because she noticed Teddy crushing on Owen.
On Richard's first day back, he asks Derek for a low stress day so he can ease himself back in. This does not happen for Richard when a prestigious doctor, Harper Avery, arrives at Seattle Grace with abdominal problems. He specifically requests Richard to perform the surgery. Derek agrees even though he does not think it is a good idea.
Cristina is ecstatic that Harper Avery is in their hospital and is eager to impress him. She breaks the rules to perform a lung surgery without Teddy knowing. Teddy was initially furious, and then calmed down knowing the procedure went well, and the patient had no chance of a lung transplant.
It is revealed that Harper Avery is Jackson's grandfather. Jackson does not like acknowledging this and the large footsteps he has to fill. He talks to Meredith about this since she can relate.
Richard is worried about the surgery he is about to perform and confesses to Derek that he wants a drink and asks him to hand the surgery over to Miranda. Derek insists on Richard performing the surgery, with Miranda assisting. During the surgery they realize that Harper is allergic to his sutures, which he picked himself.
Eventually, Mark finds out about Lexi and Alex. Alex gets mad at Lexie for telling Mark, but it was not her. The girl's night out is held in the baseball field. Cristina tells Meredith that she is in love with Teddy because her heart is in her scalpel.