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Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.
Part 2 of a three-hour season finale. This episode is the first hour of a two-hour episode which is two hours long and will air on a Monday in a different time slot than it would on Sunday. Aired on Monday, May 15, 2006 from 9 PM EST to 10 PM EST.