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The doctors of Seattle Grace are faced with the aftermath of last season's plane crash. As they try to move on with their lives, they must learn to adapt to the changes, cope with their losses and move forward with their relationships and careers.
The doctors try to cope with the heartache and injuries caused by the plane crash; everyone at Seattle Grace struggles to return to normalcy amidst the chaos.
The survivors from the crash are asked to make an almost impossible decision that will affect the rest of their lives. Meanwhile, tension grows between Jackson and April after they're forced to work together, and Alex tries to restrain himself with one of the interns.
Aware that Derek might never operate again, Meredith stops talking about the surgeries she's performing. Meanwhile, Richard calls on Dr. Catherine Avery to help him perform a complicated procedure, as things continue to heat up between Jackson and April; and Arizona's struggle to accept her fate forces Callie and Alex to face their guilt.moreless
As Meredith and Cristina rely on each other as they cope with increasing responsibilities at their respective hospitals and cope with life after the plane crash; Cristina helps Dr. Thomas with a challenging heart surgery.
As the doctors continue with their lawsuit, they're forced to confront the realities of their injuries. Meanwhile, Bailey tricks Arizona into helping her with a pediatric case, and Cristina tries to find normalcy in her new environment.
Cristina and Owen continue to figure out their relationship amidst the pending lawsuit; and Bailey argues with Ben over plans for their upcoming nuptials.
The new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty.moreless
As the rest of the doctors prepare for Bailey's wedding, Richard helps her through a bout of pre-wedding jitters. Meanwhile, Lizzie butts heads with Meredith, and Callie and Jackson try to convince Derek to participate in a risky surgery that could fix his hand.
Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.
Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark's old patients.
The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.
As Derek and April work around the clock to find a solution for the hospital, Cristina struggles to respect the wishes of a family whose son is dying. Meanwhile, Arizona empathizes with a teenager who faces problems similar to her own.
Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.
Callie comes up with an idea to save the hospital while Owen addresses the plan to sell to Pegasus to the doctors and nurses. April's date surprises her with a secret of his own.
While the hospital is hanging on a thread, the team looks for an investor to help them purchase the hospital. All while keeping Owen and the Pegasus team in the dark about their good intentions for the hospital.
The hospital new management causes a physician to question her future at Seattle Grace. The doctors and interns juggle transplant patients, each of them come with their own obstacles.
Meredith freaks out when she hears all the conditions her baby could be born with as she finds out what the sex of her baby is. Callie and Arizona set another step in their post-plane-crash relationship and the new board finds out running things isn't as easy as they imagined.
A gas tanker explodes on a Seattle highway, causing multiple injuries -- including paramedic Matthew; Meredith and Jo help a frantic mother (Sarah Chalke) whose child is suffering from a mysterious illness; and Owen bonds with a young boy whose parents are in critical condition. Meanwhile true colors are revealed when Alex is forced to work with Jo's boyfriend on an ailing patient.moreless
Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children's future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.moreless
Bailey finds herself at the center of a CDC investigation surrounding the death of several of her patients, as Jackson and the rest of the board members argue over how to address the crisis with the public. Meanwhile, Cristina teases Alex about his unspoken feelings for Jo, and Owen continues to take special care of Ethan as the condition of his parents remains uncertain.moreless
The doctors reach out to Bailey but she continues to shut everyone out; after an incident with Ethan's grandmother, Owen fears the child could end up in foster care; and a new craniofacial specialist arrives at Grey Sloan Memorial Hospital to work on a young patient; meanwhile, a magician's assistant is rushed into the ER after a magic trick goes terribly wrong.moreless
The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle; Owen's desire to be a parent gets stronger as he becomes closer to Ethan; and one wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.moreless
The storm rages the Grey Sloan Memorial Hospital and resources become scarce. One doctor goes to labor, another doctor's affair found out and an engaged doctor have second thoughts about marriage.