Goof (editing continuity): When Jamie, the girl with the brain abnormality, is being examined by George, it is obvious that the shot of the twitching leg is not actually Jamie. Although they have the same purple socks and dipaer, when you see the leg you can also clearly tell that the child has no shirt on, while in the next shot Jamie is wearing a shirt. There is an adult hand holding the hand of the child in the leg-twitching shot, but Jamie's hands are in her lap a second later.
Goof (storyline continuity): In this episode, Izzie is overwhelmed when she finds out about Meredith sleeping with Derek; nonetheless, in the pilot episode, when Cristina is mad at Meredith she yells at her how she slept with her boss, and Izzie is present in the conversation, so, she would already have to know about Meredith's fling.
Goof (editing continuity): When Cristina is turning around to look at the observation window in surgery, she has her head turned half way up, the camera angle shifts, and it is suddenly back down again and turns all the way again.
Goof (storyline continuity): When Claire is admitted we are told that she passed out in the shower. Although, when Meredith sees Claire's scars on her abdomen, Claire requests for Meredith not to tell her parents. Her parents seem equally clueless. But if she collapsed in the shower, wouldn't her parents have seen those scars? Unless she was showering fully-clothed.
Possible Explanation- They talk about her going to college and coming home at Christmas. It's possible she lives in a dorm and not at home and this is where she passed out. So her parents wouldn't have seen her stomach. They would have met her at the hospital.
Goof (editing continuity): As Izzie is leaving the house in the morning, she is carrying a purple travel mug, as she gets out of the car to enter the hospital, she is holding a disposable coffee cup, and as she leaves the locker room, she is once again carrying the purple travel mug.
Bailey: Cristina's got the flu. So, you need to pick up the slack in clinic.
Meredith: Look, I'll mop the floors, okay? (Bailey glares at her) Sorry, that was inappropriate.
Bailey: It's not the only thing that's inappropriate. While we're on the subject, you care to tell me what you think you're doing?
Meredith: Look, I'll jump through hoops if you want me to. But what I do what I leave this hospital is my business.
Bailey: Half this hospital knows your business. Flu isn't the only virus spreading around here.
Meredith: I made a choice, and I know you don't respect me for that choice. But I'll live with the consequences.
Bailey: Then I'll have lots of hoops for you to jump through.
Meredith: I've done everything you've asked me to do. I may not do it your way but it gets done. So whatever else you got, bring it on.
Izzie: Ew, what smells?
Meredith: That would be me, or more specifically, my patient's insides all over me.
Izzie: That makes me strangely happy.
Cristina: Oh, God. Oh, Meredith, you smell like...
Cristina: Something vile is stuck in your hair. You know, just go stand over there, please.
Meredith: Ugh, how much do I love being a surgeon right now?
Meredith: What does karma have to do with anything?
Izzie: I'm just saying, you've been given all the best surgeries. And now you smell like putrid goo. And you're giving off a stench. Karma's a bitch.
Bailey (walks in): Dr. Shepherd needs an intern in surgery. Which one of you is clear?
Cristina: I'm good, Dr. Bailey, where do you want me?
Bailey: You need to lie down somewhere.
Cristina: I'm fine, I'm completely healthy.
Izzie: Of course.
Meredith: What is your problem?
Izzie: Um, you! 'Cause apparently you can help Dr. McDreamy in ways the rest of us can't.
Meredith: You did not just say...
Izzie: Yes, I did!
Bailey: Hey! (to Cristina) Hemispherectomy in OR 1 with Dr. Shepherd. Go. (Cristina and Izzie leave) Apparently, I'm not the only one with hoops.
Burke: Hey. Whoa. Got the flu?
Cristina: Yeah, and thanks for it. It's making my life so much easier.
Burke: I didn't give it to you. It's all over the hospital. You should be in bed.
Cristina: Disease, diagnosis and prescription from one man.
Burke: Seriously, I'll give you a ride home.
Cristina: This is not gonna make me go home. You go home.
Burke: But I feel fine.
Meredith: Yikes, wouldn't want to meet you in a dark alley.
Cristina: Right back at 'ya. (Alex jogs up)
Izzie: A run? You run?
Alex: Every day, babe, every day.
Meredith: Not suffering enough?
Alex: What doesn't kill you, makes you stronger.
Cristina: Don't go acting all indefatigable. You're dragging like the rest of us.
Alex: Oh, what is that, professional weakness, Dr. Yang?
Cristina: It's called the flu.
Alex: Yeah. (interns are in the locker room)
George: I'm gonna need a major rush to make it through this day. I need a kick-ass surgery.
Alex: Ooh, you a bad boy last night, George?
Izzie: That would be Meredith.
Alex: You a bad boy, Meredith?
Cristina: Do tell.
Meredith: Nothing to tell.
Cristina: That says it all, huh? (Izzie slams her locker door)
Meredith: Sorry, I have a sex life.
Alex: Don't apologize. Embrace it. Share it. Count me in.
Izzie: Yeah, next time, just let me know if I need to go to a hotel so I can get some sleep.
Meredith: Am I missing something?
George: You were just a little loud. (everyone leaves but Cristina and Meredith)
Cristina: Do they know its McDreamy keeping them up all night?
Meredith: I hope not. I already have Bailey riding me, I don't need my roommates thinking I'm getting special treatment.
Meredith (opening voiceover): Okay. Anyone who says you can sleep when you die... Tell them to come talk to me after a few months as an intern. Of course it's not just the job that keeps us up all night. I mean if life's so hard already, why do we bring so much trouble on ourselves. What's up with the need to hit the self-destruct button?
Burke (taking the X-ray and showing it to Bailey walking by): You remember this guy?
Bailey: Hey, the tattooed masochist.
Burke: Had himself shot again.
Bailey: Glad to see he's still stupid.
George: Yang. I'm scrubbing in on a hemospherectomy with Shepherd.
Cristina: Get out! I would kill for that.
George: We're cutting out half the girl's brain, and it's going to work. It's outrangous. Almost makes it kinda hard to hate him.
Cristina: Why do you hate him?
George: Oh, no reason.
Cristina: Oh, you know about him and Meredith?
George: You know?
Cristina: When are you gonna figure out that I know everything?
George (to Izzie who is walking up the stairs): She knows.
Izzie: Oh, about doctor-cest?
Cristina: It's been going on for, like, ever.
George: And you didn't tell us?
Cristina: Ooh, you're a gossip, huh?
George: I am not!
Izzie: I am!
George: He's about to go into major brain surgery on no sleep? That's not very responsible.
Cristina: Jealous, much? Sex all night isn't about being reponsible.
Izzie: No, it's about sex all night. I can't believe you're not pissed off about this, you of all people.
Cristina: Well, she works hard all day. She's good at her job, why should you care how she unwinds? I mean you like to bake all night. Some people like to drink. Others like an occasional screaming orgasm.
Alex (walking up): Yeah, we do. Forget I said that. Pretend like I'm not here. Continue. (to Cristina) You look like you need to be spoon-fed.
Cristina: You look like Alex.
Meredith (closing voiceover): Maybe we like the pain. Maybe we're wired that way. Because without it, I don't know, maybe we just wouldn't feel real. What's that saying? Why do I keep hitting myself with a hammer? Because it feels so good when I stop.
George: You get any sleep?
Izzie: She should oil the bedsprings, as a courtesy, or at least buy a padded headboard.
George: So, who's the guy?
Izzie: You think it was just one guy doing all that work?
George: Yeah, do you mind if I don't think about that?
Izzie: Oh, jealous?
George: I'm not jealous.
Izzie: Well, I am. Least I know she'll be having a long day at work. (they see Derek leave) Well, at least we know brain surgery isn't his only skill.
George: They can't be...He's her boss.
Izzie: We're late. He's all of our boss. You know she has been scrubbing in a lot lately on his surgeries.
George: No, Meredith wouldn't sleep with him just to... No.
Izzie: Well, if she's not ashamed of it, why is she keeping it a secret?
George: Maybe she didn't. Maybe it just happened. You know, spontaneously, last night.
Meredith (walks in the kitchen): Hi. Good morning.
Izzie: Morning. Hey, so it sounded like you were having some pretty radical sex last night, all night long. Who was the guy?
Meredith: No one you know.
Izzie: We're late. Let's go.
Meredith: Thought you'd be asleep by now.
Izzie: Yeah, well ... I'm not. (pause) If you wait a few minutes, you can have a piece of cake. Baked it chock full of love. Actually, chock full of unrelenting, all-consuming rage and hostility, but -- still tasty.
Meredith: So you know?
Izzie: I know.
Meredith: Well, do you want the long, sordid version, or do you want the short version where I started sleeping with a guy who turned out to be my boss?
Meredith: Izzie, cut me some slack here.
Izzie: No! You went to Dartmouth. Your mother is Ellis Grey. You grew up -- look at this house! You know, you walk into the OR, and there isn't anyone who doubts that you should be there. I grew up in a trailer park. I went to state school. I put myself through med school by posing in my underwear. You know, I walk into the OR, and everyone hopes I'm the nurse. You-you have their respect without even trying, and you're throwing it away for ... what? A few good surgeries?
Meredith: No, it's not about the surgeries, it's not about getting ahead.
Izzie: Then what, a little hot sex? You're willing to ruin your credibility over that? I mean Meredith, what the hell are you doing? (Meredith rolls her eyes) Oh my god... you're falling for him.
Meredith: I am not.
Izzie: Oh you so are.
Meredith: No, I'm not.
Izzie: So are... Dammit. You poor girl.
Meredith: You know, it's just that he's - he's just so- And I'm just... I'm having a hard time.
Izzie: You're all, uh, mushy and warm... and full of secret feelings. (hands a slice of cake to Meredith)
Meredith: I hate you! And your cake!
Izzie: My cake is good. (pause) So, uh, how hot is the sex?
Izzie: What? C'mon, I'm not getting any. Help a girl out with a few details.
Meredith (talking to the parents of a teen patient about the gastric bypass surgery she had done illegally): Gastric bypass is a procedure normally done on obese patients to help them lose weight.
Mr. Rice: Claire? She doesn't need to lose weight!
Mrs. Rice: Are you kidding? This means the world to her! But it is so typical of this girl to take the easy way out. She's done it with everything since she was a little kid.
Bailey: Mrs. Rice, nothing about this is going to be easy. She's gonna face a lifelong struggle with malnutrition unless she has surgery to reverse the procedure.
Mrs. Rice: Do the surgery. I told her to watch the freshman 15! Don't eat junk, exercise. But when she came home for Christmas, who had to take her out and buy her a brand-new pair of size 6 jeans because she couldn't get into the ones I got her last summer?
Mr. Rice: Tina, she... she tries so hard. She does. She gets good grades. She gets A's!
Mrs. Rice: Yeah, and then she gets illegal surgery in Mexico.
George: I'm sorry, but did you just.....have you been drinking?
Dr. Taylor: I beg your pardon?
George: Do you smell.....? I smell alcohol.
Dr. Taylor: Where the hell do you get off accusing me of something like that?
Derek: George, you're out of line.
George: There are rules. You know, there are rules for a reason. There is a 2-year-old girl on this table! You shouldn't take advantage of someone else's vulnerability.
Dr. Taylor: I don't need some punk intern telling me what's at stake here. (to Derek) Get him out of here, Shep. Shep?
Derek: You're out, George.
Mr. Rice: We're just concerned. Where did you get the idea to do this?
Claire: The Internet.
Mrs. Rice: Honey, there is a healthy way to lose weight.
Claire: Yeah, I tried that, but it doesn't work for me like it does for you.
Mr. Rice: You don't need to lose weight--
Mrs. Rice (cutting him off): What are you eating, and how much have you been working out? You know, most of the time, when people hit their target weight, they have to work really hard to stay there.
Claire: Everyone gains weight in college, Mom. It's... it's stressful. There's not enough time to work out. I just thought that if I didn't have to worry about my weight, I could... focus more on my studies.
Mrs. Rice: So you took yet another shortcut? Life doesn't work that way, Claire!
Mr. Rice: Tina!
Mrs. Rice: What? You want to argue this?
Derek: Let me explain.
George: It's fine.
Derek: No, there is a code among doctors. We're not supposed to ask each other questions, not within the walls of this hospital.
George: Okay, I was out of line.
Derek: No, you weren't. I was. I was out of line. Somebody should have taken responsibility. It should have been the guy doing the cutting. It should have been me. You didn't deserve what happened to you today. You did the right thing code or no code. (extends his hand for George to shake, George hesitates then shakes his hand) You saw me leave the house this morning, didn't you?
George: Oh, was that you?
Derek: Hmm. I'm not using her. And I don't favor her.
George: She's pretty great, you know.
Derek: Mm-hmm. So, come on, lets go tell Jamie's parents she's gonna be fine, barring any complications.
Meredith: I need a shower.
Bailey: I need a shower. You need to go tell that girl's parents what kind of kid they're getting back.
Meredith: You're not gonna let me shower first?
Bailey: That would be a hoop, would it not?
Meredith: It would qualify.
Bailey: Shower first, then.
George: Hey, hey, hey. Have you seen Shepherd?
Izzie: Not as up close as Meredith has.
George: What? Are you trying to get her in trouble? She's our friend.
Izzie: George, this program will make or break our careers. Some of us will make it through, and some of us won't. And that decision depends entirely on recommendations from doctors like Shepherd. There is a reason we don't sleep with the attendings.
George: It's not her fault, okay. It's Shepherd's. He's the attending, he should know better. He's taking advantage of her.
Izzie: It didn't exactly sound like anything was happening against her will last night.
Although credited, James Pickens, Jr. (Richard Webber) is absent from this episode.
Original International Air Dates:
Australia: September 19th, 2005 on Channel 7
Sweden: January 3rd, 2006 on Kanal 5
Netherlands: February 14th, 2006 on Net 5
Germany: April 25th, 2006 on ProSieben
Croatia: October 16th, 2006 on NOVA TV
Finland: October 18th, 2006 on Nelonen
Portugal: December 10th, 2006 on RTP1
Romania: February 20th, 2007 on TVR1
Serbia: February 2nd, 2008 on B92
Music Featured In This Episode:
1. Downtown by Tegan and Sara plays when Izzie and Meredith argue in the locker-room,
2. Hummingbird by Wilco is the one played at the end of this episode,
3. Suitcase by Joe Purdy plays while Alex's patient dies,
4. Wish I by Jem plays at the beginning of this episode.
Episode Title: The Self Destruct Button
The title of the episode is a reference to a song. The Self Destruct Button is title of an AC/DC song. It is also a song by Dana Monteith.