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This episode is named like Nirvana's song, "Heart-Shaped Box"
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A woman in New England was really saved by having a heart transplant in which the organ, in fact, was preserved in a box.
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Chyler Leigh (Lexie) does not appear in this episode.
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Derek is blacklisted from ever doing a clinical trial again.
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Mark says about making a patient looking like Frankenstein but Frankenstein is not the name of the monster that he was alluding to. Frankenstein is instead the name of the scientist who created the monster.
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This episode spans the time of three months.
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Callie and Mark's baby's name is: Sofia Robbin Sloan Torres.
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Goof: Richard, Bailey, Cristina and a med student are in a room looking at a pheochromocytoma on an abdominal MRI scan. The medical student points to the transverse colon asking if that is the tumor. Cristina tells him it's the gallbladder. The gallbladder isn't even in the image they are pointing to. Also, Cristina later points out the kidney, "adrenal gland" and tumor, even though neither of the adrenal glands is actually present in that particular slice. However, the right kidney does demonstrate a round soft tissue lesion.
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This episode originally aired just two days prior to the Tuscon Shooting.
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If you look closely at the choir singing outside the hospital, you'll notice that it is the same group of 20 to 30 people digitally multiplied to create the illusion of a mass crowd.
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In many television episodes with documentary story lines, most of the episode consists of showing the crew walking around and filming, with little attention paid to the final product. In this episode, however, the camera crew is rarely shown and the whole episode is the final documentary on the show Seattle Medical- Road to Recovery.
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Goof: During the operation, when Dr. Torres is waiting for the arms to pink up, the tattoo "Nicole" is visible the two times, that would mean that she reconnected twice the same arm. They used the same shot for both arms
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The exterior of Dr. Yang and Dr. Hunt's new firehouse apartment is Fire Station 23 at 225 E. 5th Street, Los Angeles, California, but digitally altered to look like Seattle and a lot less like the slums of L.A. This firehouse was used for the interiors of Ghostbusters headquarters in both Ghostbusters movies. The interior seen on the show is a set that kind of looks like the interior of the real firehouse - if the interior were actually under going renovation and were in a more decrepit state than it currently is in.
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A comment about Jerry being transformed from a tree to Frankenstein was made. However the reference was made to Frankenstein's monster not Frankenstein the scientist who created it.
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Sarah Drew (April Kepner) and Jesse Williams (Jackson Avery) are now credited as series regulars.
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Gary Clark was also the name of the patient from
"New History" who had a cardiac problem, and whom Cristina and Teddy fixed.
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When Meredith, Alex and Cristina are talking in the cafeteria, Meredith's yogurt moves from her hand to the table and back to her hands between shots.
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Goof:Callie's lecture was about a case that she worked on with Alex when he was an intern. In the storyshe says "In my 3rd year as a resident." but actually that would have been her 4th year. Because in the past episodes it was stated that Chief Resident is a spot for a 5th year resident. So how would she have gotten Chief Resident if she was only 4th year.
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Ellis: You can't toast a dead Irishman with a soda pop, Richard. Get this man a vodka, Frankie.
Richard: You know I can't stand the taste of that stuff.
It seems as though this is when Richard started drinking, and that he still, as Ellis suggests to him drinks vodka. The same way. Straight, with a lime.
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In episode 1 of season 2, Bailey comments that she was the only female intern of her year, but it's there were other female interns in the room when Webber was doing rounds.