This special opens with past clips from the show followed by the opening credits. The credits were done in a similar style as the series with the stars' pictures in the center of a vinyl record and the seasons 3-10 theme song in the background. Following the credits, Henry Winkler enters a nostalgia-filled set and remarks about how his years on the show were the happiest days of his professional life.
At this point, clips were shown of various scenes involving the Cunningham family. Following the clips, Marion Ross and Tom Bosley talk briefly about being "frisky," and a related clip is show. Ron Howard then talks about how Fonzie moving in with the Cunninghams impacted the show. Clips are shown. Ross and Winkler talk briefly about their characters' relationship and how Marion called Fonzie "Arthur." A never-before-seen outtake is shown where Fonzie and Marion are very affectionate with each other.
Back from commercial, clips featuring Richie are shown followed by Howard talking about having been lucky enough to be on two hit shows (The Andy Griffith Show being the other). More clips are shown featuring Richie. Ross then talks about Howard's success and how people thought she really was his mother. More Richie clips are shown. Winkler and Howard talk about how, although Howard says he was a wreck with girls when he was a teenager, Winkler thinks he [Howard] was the "water and power company." Related Richie clips are shown. Winkler talks about his relationship with Howard. Clips are shown featuring Fonzie and Richie.
A clip is shown in which Mork first meets Richie. Howard talks about Robin Williams, and more clips are shown. Howard doesn't think Williams had kissed him in an episode, but the clip is shown. Howard talks about the challenge of just keeping up with Williams in the scenes, and another clip is shown.
The next segment focuses on Fonzie. Garry Marshall talks about wanting to have a character that represented "the other side of the tracks" in comparison to the Cunningham family. He wanted a six-foot four-inch Italian guy with blond hair, but they gave him Henry Winkler. Winkler talks about his audition, and clips are shown from the show. Ross talks about Winkler's sex appeal, and more clips are shown. Winkler thinks back about how many women he's kissed on the show, and a clip is shown. Winkler talks about his "aaaayyyy" phrase, and clips are shown. Don Most talks about what made the Fonzie character: the tough exterior with vulnerability underneath. He thought of Winkler as a big brother. More Fonzie clips are shown between Most's comments.
Winkler talks about his leather jacket and how ABC didn't want him to wear it too often because they thought he would be associated with crime and being a hood. He had to wear cotton jackets instead but could wear the leather once per show or when he was with his motorcycle. Marshall got around this by incorporating the motorcycle into as many scenes as possible. Winkler talks about how the real jacket was inducted into the Smithsonian Institution in 1981. Clips of the ceremony are shown as well as the jacket housed in a glass case behind Ted Baxter's blazer from The Mary Tyler Moore Show. Howard tells Winkler how he always wanted "Fonzie's Book of Magic" that would allow him to start a jukebox by hitting it and have girls come to him when he snaps his fingers. Clips are shown.
Back from commercial, the next segment is about dating and romance. After some clips, Bosley talks about how Marion and Howard knew Fonzie had a reputation with women before he ever moved into their place. Clips are shown featuring Fonzie and Richie. Bosley talks about how Marion and Howard were concerned about Richie going out with the type of women Fonzie would see. More clips are shown. Anson Williams talks about how they did okay with women before the show, but they never did that good. Potsie, Ralph, Richie, and Fonzie clips are shown. Bosley talks about Laverne and Shirley. Clips are shown. Marshall talks about how the cast gelled so well and how the girls were given room to perform. Another clip is shown.
The next segment deals with Arnold's. Howard talks about how some of the best scenes were at Arnold's and how the dialogue would just flow when they were in the booths. Clips are shown. Pat Morita talks about how Arnold came to be the owner of a drive-in in Milwaukee. Clips are shown. Winkler and Most talk about how the guys bonded. A clip is shown. Howard talks about the ebb and flow relationship the actors had. Clips are shown. Al Molinaro talks about how he originally thought he would be out of place with all of the kids around. Clips are shown. Howard talks about how his relationships with the other guys were somewhat like those of army buddies. A clip is shown. Most, Williams, and Howard talk about their friendship. A clip of Potsie, Fonzie, Richie, and Ralph singing "Blueberry Hill" from the "Welcome Home" episode is shown followed by Williams, Winkler, Howard, and Most singing it for the special.
Back from commercial, Winkler talks about how everyone grew up during the series' 11-season run and how Richie and Joanie went from being cute kids to young adults. Clips are shown. Bosley talks about how the Cunninghams weren't perfect like some of the other television families and how Happy Days dealt with life and growing up. Clips are shown. Marshall talks about the introduction of Scott Baio as Chachi, and a clip is shown. Baio talks about how Winkler hugged him and made him feel like it would be okay. A clip is shown. Winkler talks about how fearless Baio was, and a clip is shown. Winkler gives Baio a yellow hat that was used in one of the clips. Winkler tells Baio how he went from a talented ten-year-old squirt to a talented older squirt. Clips are shown featuring the Joanie-Chachi relationship. Baio talks about his real-life relationship with Erin Moran and how that helped at times and was awkward at others. More clips are shown.
The next segment features bloopers and outtakes. A clip of Fonzie spraying Marion with whipped cream is shown. Winkler talks about the benefits of having a television family. More outtakes are shown. Marshall talks about the practical jokes that were played on the set and how many of them were originated by director Jerry Paris. He says that one of the most frequently asked questions was if Ron Howard, as Richie, was really playing the saxophone. A clip is shown where Howard stops in the middle of a scene, but the saxophone keeps playing. A bunch of bloopers are shown. Howard and Winkler talk about how they were there for the 300 people in the audience and for each other. More bloopers are shown. Bosley talks about how they were all brought together to do the show, and a clip is shown of them taking a picture.
Molinaro talks about a parade Milwaukee had for the cast. Clips of the parade are shown while he talks about how the television industry though of Happy Days as a "bubble-gum" show. The fans, however, knew how important the show was and still is. Marshall talks about the show's softball team that toured all over the United States and how it bonded the cast. Footage of the team is shown as Marshall speaks. Howard and Winkler talk about Winkler wanted to be on the team but didn't really know how to play. Howard says that he turned out to be one of the premier pitchers in the league. Clips of Winkler pitching are shown. Winkler tosses up a ball marked "Germany Road-Trip Ballgame 1982" and declares it to be one of his most treasured possessions. Winkler says that he wouldn't have been the pitcher he was without Howard, and that he was (and still is) his best friend. They talk about how hard the "goodbye" scene from "Welcome Home" was to do, and the clip is shown.
Each cast member expresses their thoughts about being on the show. The final scene from "Passages" is shown, and Winkler remarks about how they were all together at the end. To close the show, Winkler thanks the viewers for being a part of their family again, and everyone says, "Here's to happy days."