Learn a lesson from this one, television writers everywhere. Put your characters in a limited setting and see the sparks fly. (Okay, it didn't work with snakes on a plane, but that was just a pun turned into a movie.)
Putting Cuddy and House on a long flight is asking for (delicious) trouble. Confronting the sarcastic House with a group of patients/passengers that are even more stressed out than usual, brings it all up a notch. Add to this the recognition anyone who has ever suffered through a horrible flight, will feel, and you get a nearly perfect episode. Nearly, not completely. In the previous episode Cuddy disagreed with House and won. Now she can't understand that (-spoiler-) she is suffering from hysteria? The subplot of Cameron and Chase is quite tiresome. Luckily, Wilson gets to shine in those scenes, something that was long overdue.
Also, give a raise to the researcher/writer who discovered in their medical journals that (-spoiler-)a person recovering from a diving accident would get into trouble on an airplane. Wonderfully ironic.