House

At a giant heart exhibit at a children's museum, a group of kids are on a tour. A young boy Ian needs to go to the bathroom, but then the teacher goes into labor and notices the boy is bleeding from the anus.

The clinic is hosting a charity poker tournament and House, Wilson, and Cuddy spar over a hand. They're interrupted when Ian is brought in and he's Cuddy's patient. House takes an interest but Cuddy prefers to remain at the table, unconcerned. He folds and goes to see Ian, and concludes his brain is losing connection to his body. He checks an old file then calls in his staff to check out the case. He compares it to the case of a 73-year old woman from 12 years ago, and predicts Ian will have kidney failure. The woman died after the same progression of symptoms. Chase recalls that House checked out a patient with similar symptoms but it turned out he didn't have the same illness, and claims House is obsessed with the case and sees the symptoms everywhere.

Cameron talks to the parents and Foreman finds purple papula like House predicted, but nothing or anything else to explain the bleeding. The test for Erdheim-Chester proves negative. House orders a kidney biopsy and meets with the patient, and determines that his kidneys are shutting down as predicted.

It's back to DDX as they consider the new symptoms but nothing matches up. Foreman wants to call in Cuddy as Ian is her patient, but House gets Wilson to distract her by setting him up to lose so she'll stick around. Cameron tries to reassure the parents without much success. Foreman and Cameron report they found a small mass on the pituitary gland, predicting lymphoma. However, the tests for lymphoma show negative. House then breaks into the cafeteria and grabs a coffee, while predicting the next symptom, liver failure, will kick in in 90 minutes. House orders any and all possible treatments then calls Wilson to help him win to keep Cuddy going.

The liver continues to function but Ian's platelet count drops, but House believes it's a good sign for no other reason then it's a different symptom. Ian goes into respiratory distress and House adds it to his list of symptoms. He concludes that Ian is getting worse, and faster then his original patient. They need an oncologist and House calls Wilson to get a consult. House tells Wilson to go all in and he wins, much to House's surprise. Wilson finally comes up when House tells him what's going on, and tries to determine why their interferon treatment caused the respiratory distress. Wilson determines that Ian might have Kawasaki's, which doesn't affect the elderly and might account for Ian's problems. They check his arteries for aneurysms and it turns up negative, but they see a small mass in his heart. House orders a biopsy and probes the heart, and Ian goes into coronary failure. They manage to revive him after eight minutes and then House continues the probe.

As they continue the DDX Cuddy hears from the parents and comes in to check up and order House off the case. House gives them the papula which is all they have, and they can do maybe three tests on it. The tests prove negative for what they're looking for and they're running out of samples. With only one test option remaining, House goes to see Ian and he and Cuddy have a moment. House then goes outside where he talks to Wilson, who announces he won the tournament with a pair of hidden aces. House orders a test for Erdheim-Chester, which they've already tested for and proved negative. House figures it hadn't reached Ian's gastro-intestinal tract yet but now it's active. House overrides them and orders the last test, and it turns out...positive. They give Ian the proper treatment and he revives. As they take down the decorations for the poker tourney, House and Wilson play a hand and