House exacts revenge on a former medical school classmate, Philip Weber, who turned him in for cheating on a math test. Seems this guy has published his research on a migraine remedy in an Indian medical journal. House seeks to prove him wrong by trying out the medication on himself - after inducing a killer migraine. Of course, Weber's medicine doesn't work, leaving House with not only pain in his leg, but pain in his head. Needing to rid himself of the headache, House ultimately resorts to LSD (which was, in fact, invented to treat migraines) combined with antidepressants (which mitigate the psychedelic effects of the acid). As House tries to disprove Weber, he treats a burn victim, who has crashed his ATV.
Favorite moments: Wilson believes that House hatches his elaborate plot as a distraction after losing Stacy, suggesting that his friend hire a hooker (among other things) instead. In the final scene of the episode, House desolately awaits his lady of the evening. As he lets her into his apartment, it is clear that House hurts, not just in his head, not just in his leg, but in his heart as well. Also, Cameron's examination of House when he is tripping on LSD is a delight.