
While House and his team treat a blind man, House's mother Blythe tells her son about her new relationship.

Chase forms a bond with the team's newest patient, a cloistered nun ready to take her vows. Meanwhile, House and Taub engage in a war of pranks.

When one of House's team is injured during an encounter with a violent patient, Foreman's mentor Dr. Walter Cofield reviews the incident and must sort out the truth from the embellishments.

An underage runaway's symptoms grow worse after she's brought in for treatment. When the team determines that the girl needs invasive surgery, they have to find her mother, who turns out to be a former drug addict. Meanwhile, House tries to blackmail Foreman using the hospital director's affair with a married woman, and Taub tries to connect with his infant daughters.
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House and his team treat an Alzheimer's patient who flies into violent rages and throws up blood. Meanwhile, Wilson copies with a patient who claims that there is no sexual relationship in her marriage.

The team takes on the case of a prosecutor who they initially believe is suffering from hyper-anxiety, but soon discover has paranoid delusions. Meanwhile, Chase and Taub take an interest in Foreman's social life, Park starts to get into the swing of things when House preys on her paranoia, and Wilson becomes obsessed with learning if House has a gun.
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A 14-year-old girl admitted for an allergic reaction gets increasingly worse. However, House would rather pursue the case of a deceased four-year-old and will go to any lengths to solve it... including going back to prison. Meanwhile, Park wonders why Chase is obsessed with personal grooming.

House and his team treat a teenage boy who requires a bone marrow transplant, and discover a disturbing family secret. Meanwhile, Taub tries to cope with the fact that his ex-wife wants to take their new daughter and move cross-country, and House schemes to get rid of his ankle monitor and go to a boxing match.
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A community leader hiding dark secrets becomes ill and confesses everything... compromising his chances of receiving proper medical treatment when he antagonizes his friends and family. Meanwhile, House becomes obsessed with convincing Taub to prove that he's the father of his two six-month-old daughters.

House attempts to negotiate with a wealthy patient who is planning to relocate his labor force to China. Meanwhile, Foreman chairs Park's disciplinary hearing, while Adams assesses her own ethics when she learns of their patient's relocation plans.

House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Thirteen to help them confirm whether Benjamin is in his right mind or not. Meanwhile, House cons Dr. Adams into volunteering her time as part of his team.
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Foreman brings House back to Princeton Plainsboro under parole to deal with an infected pair of lungs needed for a transplant patient. House is forced to work with a timid intern, the loss of his former team, Wilson's hostility, and a new set of rules to find a cure in time to save the patient.
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A year has passed since House ran Wilson's car into Cuddy's living room -- and House has spent most of it in prison. Now House only has to stay out of trouble for five days to win his parole. However, events conspire against him when a mysterious ailment strikes a fellow prisoner while a gang leader wants House to procure pills for him.
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