At a fairground, Rob tries to get his daughter Alice on a ride. Alice's reluctant but eventually agrees to keep him happy. she starts screaming… and doesn't stop even when the ride does.
At the hospital the father and his divorced wife argue over the patient while Cameron tends to Alice. Cuddy meets with some donors while House enjoys himself shining a pointer on her while waiting for her to give him his (limited) dosage of Vicodin. House stops in to check on the differential on Alice and suspects a disappearing gall stone. While Chase complains about the fact he was left out of his father's will, Cuddy meets with Tritter who points out that if his pressure on Wilson won't work, he'll start on the rest of the staff. Cuddy denies that House has a problem but Tritter thinks she's failed to deal with him.
Alice's parents argue over whether she should have surgery or not, and the mother overrides both her husband and House to prohibit the surgery. House takes them to a judge and wants her to grant them a motion to perform the surgery. The judge goes ahead and afterward Alice complains about the stitches and painful skin. Foreman checks and finds a rash on her abdomen.
It's back to differential but the staff has problems as they deal with the fact Tritter has frozen their accounts. House is more concerned about his patient and sends them to run tests on Alice. Wilson comes in to the lounge to gripe to House and Chase reports that the scratch tests are showing that Alice is allergic… to everything. House suspects infection and has her take a bite of (Wilson's) sandwich. When she eats it, House determines she's not allergic to peanuts, disproving Chase and Foreman's diagnosis. House orders drugs that may shut down her system and the father Rob refuses to let him do it but his wife Edie wants House to treat her. It's back to the judge who gives temporary guardianship to… Dr. Cuddy. She's not too thrilled.
Tritter talks to Foreman and threatens to put his brother Marcus away, and offers parole for him in return for Foreman's testimony. When Foreman doesn't cave, Tritter suspects he'll do it just because of House's hypocrisy.
Although House suggests broad-spectrum antibiotics, Cuddy orders a narrower range for Alice and while Edie and Rob argue, Alice's heartbeat and blood pressure goes up and Cuddy orders them out. Meanwhile Chase and Foreman start sniping at each other about who made a deal with Tritter, when Cameron comes in to tell them Alice has apparently disappeared. Rob brings her back as she's collapsed, suffering from muscular rigidity.
It's back to differential but House is distracted by his growing pain and Cuddy refuses to prescribe for him. House suspects one of the parents gave her aspirin, triggering Reye's Syndrome, but both of them deny giving her any. Edie reveals that she left Alice with a baby sitter and House has Cuddy put her on dialysis, and she gives him a few Vicodin. Cuddy tries to reassure Alice without much luck, telling her that her parents might get back together.
Tritter works on Cameron and accuses her of being in love with House. He then notes that Cameron actually turned herself in when she ended up cheating on a test, and he notes that House has changed her. Cameron walks out on him.
Alice starts to react to the dialysis as her left arm turns pale from lack of blood due to a clot and they take her into surgery. Tritter meets with Chase and notes that he lied about having his accounts frozen. He then threatens to make it appear that Chase did rat House out to get him to rat House out. Chase isn't thrilled.
In the OR, Alice's temperature goes up and Cuddy tries to cool her down while House, Chase, and Cameron wonder if the diagnosis of Reye's was wrong, but House is still distracted by the pain. He finally notices that Cuddy has taken her into the shower where Alice's infection breaks out again because of Cuddy going with the limited antibiotics, and House snaps at her for her poor mothering skills.
It's a new differential, and House suspects it's something they haven't touched on yet, but a broad-spectrum antibiotic won't work any more. The staff reveals Tritter released their bank accounts but House isn't concerned, and doesn't want to hear Chase try to explain one way or another.
Wilson meets with an upset Cuddy who believes House deliberately went after her attempt at motherhood. She admits that her three implantations haven't worked and she's awkward with Alice.
House believes the infection has moved into Alice's muscle sheath on her left arm and leg and there's no other option except amputation from the flesh-eating bacteria. Time is running out and House snaps at his staff before going with Cuddy to tell the parents. As Alice goes into surgery, the others discuss the case and Chase realizes that House was wrong… she's allergic to light and got worse every time she goes into surgery. When Chase tries to get him to stop the surgery, House slugs him… but Chase continues with his theory of why her liver is shutting down. House realizes he's right and they stop the surgery just in time. Later Cuddy reassures the parents but they note that it's genetic and they're both carriers.
Later Chase and Wilson talk in the lounge and Chase realizes it didn't' matter that he solved it and House didn't. Later Tritter meets with… Wilson.





