House

A Coast Guard rescue team is picking up a Cuban couple stranded in the water. They have the woman on board but the man refuses to give up the suitcase he's holding. They eventually get him on board when he drops the suitcase, and he reveals the suitcase held his ailing wife's medical records… and they need to see Dr. House.

The couple is admitted to the hospital where Cuddy tries to get hold of House, who is busy watching Foreman in the cafeteria. Wilson points out House should try to convince Foreman to stay but House isn't interested. He notes that House isn't good with change, and is still playing the same guitar he's had since eighth grade. House orders Chase and Cameron to check up on Marina and her husband Esteban, but Foreman is distracted and busy elsewhere. They come back and Chase points out to Foreman that neither he or House want to leave, and wonders what Foreman does want. Foreman determines that Marina has MS and suggests interferon treatment. House agrees and (mildly) expresses his appreciation for Foreman's contribution.

Foreman administers the interferon and her pain gets worse, and he inadvertently breaks her wrist. House dismisses Chase belief that infection is responsible and House believes it's cancer… which Foreman also believes is responsible. Chase is angry that House is going along with whatever Foreman says and later confronts House in his office. Before he can say anything, House fires him and says he's been there long enough and it's time for a change.

As Cameron and Foreman run a MRI on Marina, Chase comes in to tell them the news. Chase notices she has a hot spot. Everyone storms in to confront House over firing Chase and Cuddy tells him to unfire him. House refuses even when Chase calls in to reveal that Marina has a blood clot in her arm. Foreman explains to Esteban that the blood clot means Marina has a heart problem and Esteban insists on seeing House, who hasn't visited yet. Foreman has Esteban sign a consent form for the treatment and then gives him House's home number. Esteban continues to call throughout the night while Cameron wants to know what Foreman had to do with Chase's firing while they administer a catheter. House comes in rather than talk to Esteban just as Marina's pulse stops… even though she's still talking and breathing. House has her cough to keep the blood flowing into her head and then they administer CPR rather than bypass to damage the heart. House leaves them to take care of Marina and has a meeting with Wilson in the middle of an operation, via television. Wilson believes it's human error on Foreman's part but House doesn't believe it.

The team continues to administer CPR while Esteban wonders what's going on and Cuddy brings a student through. House interrupts her to ask her what might have caused the heart stoppage. When Cuddy finds out Marina isn't on bypass, she orders him to do so. Later Esteban confronts House and demands answers. House decides to look directly at Marina's heart and has them jumpstart the heart to no effect, and the attending surgeon declares her dead.

Foreman is packing when Cameron arrives to give him a going-away present: the article he stole from her. Foreman admits he'll miss her and House sends them home. They want House to tell the husband what's going on but House refuses until they have answers. Cameron visits Chase at a diner and he admits it is time for a change and House was right. He also admits his "thing" with Cameron was silly and she says she'll miss him, but leaves before anything else might develop.

Cuddy confronts House and accuses him of caring, but he denies it. She tells him it's time to let go and he goes to Esteban, who is praying in the chapel, and tells him his wife is dead. Esteban goes to visit her one last time before they shut down the machine maintaining her heart. The machines are shut down but Esteban detects a heart beat and shows House, believing it's a miracle. Marina wakes up and House wonders what has happened.

House meets with Cameron and Foreman and still insists there's some reason, even though the pain is gone. House suspects a genetic defect in an artery and orders another angiogram, then goes to see the couple. He tells them he needs to fix the heart and asks permission to do another angiogram, and admits he was wrong but they need to put Marina in his hands, not God's. They go ahead with the angiogram and they find the cause, which can be fixed with surgery.

Later Cameron goes to Chase's house and says it's Tuesday: it's Monday but she didn't want to wait. They kiss on the doorstep.

House is having supper when Wilson comes in just as Foreman is leaving. House finally breaks down and asks him to stay, admitting Foreman is an important part of the team and needs him. Foreman still plans to leave, saying he's more interested in saving people then solving mysteries. House accuses him of drawing out his whole resignation, and Foreman just leaves without saying a word.

House goes to visit Cameron, who hands him her resignation letter. Cameron figures he'll be fine and she admits she'll miss him as she leaves.

Later House and Esteban share a drink and cigars over the sleeping Marina. House admits that he's okay but doesn't know what he's going to do next. Later as he walks down the street and finds a large box waiting for him. He takes it into his apartment and opens it to reveal that he's finally bought a new guitar.