For many House fans an episode centric on Masters might prove too much. But I find her character rather earnest and appealing because she is such a contrast to House, and to his egotistical, eccentric way of dealing with cases. I like this story because it pushes her character to the limits, and how she lies to save the patient's life. In the backdrop you have the rather amusing Hilson (House/Wilson) love affair involving chickens.
As a long-time companion she might have become a problem with writers on the show, because it becomes rather repetitive if you argue the whole ethics/morality in every issue they appear. But this episode rather nicely rounds off her story, and is one of the finest stories of the season.