Fitness guru Emmy is filming a commercial at a stadium while her overweight clients exercise behind her. One of them collapses and Emmy helps him up and tells the other s to keep running. She insists on exercising with them so it looks real. She runs with the man up to the top… and then collapse, falling down and breaking her ankle.
Cuddy catches House in the elevator and gives him the case, and informs him that she'll be sharing his office since the recent hostage situation destroyed it. House meets with Kutner and Taub, since Foreman and Thirteen are in the clinical trials. Kutner is familiar with Emmy and suggests allergies. Cuddy, in the office, points out the flaw in that differential and suggests that cold air and exercise is setting off asthma. House notes that there's no high blood pressure and gets Taub and Kutner out… and tells them to check Emmy for asthma by recreating the conditions of how the attack occurred.
As Thirteen waits for the clinical tries in the waiting room, she sees a female patient with advanced Huntington's, and remembers her mother having the disease when she was a child.
Taub and Kutner take Emmy to the refrigerated morgue and have her exercise. She insists on exercising and Taub wonders if she ever indulges. She says she never does… and then collapses.
Foreman conducts tap testing on Thirteen, who insists on talking about how she shouldn't be there when there are others. Foreman insists she's just there because she has Huntington, and tests again after telling her not to talk. She keeps talking and he finally confirms that she's suffering nerve degeneration.
Cuddy is playing with House's ball, irritating him, and he says they should split the desk. She readily agrees and he warns her that being nice won't work. Taub and Kutner report about Emmy's new condition and that her heart stopped. Asthma isn't responsible for her symptoms. Kutner suggests a carcinoid tumor strangling her system and House tells them to find it and cut it out.
As Kutner and Taub scan Emmy, Kutner asks for Taub's input on a leaking breast implant that might cause join pains. Kutner explains that he's set up a web site that provides medical advice and second opinions. Taub wonders if Kutner wouldn't mind if he told House, and Kutner admits he set it up in House's name. Taub threatens to tell House unless he gets a 30% cut. They're interrupted when they discover that Emmy has a shrunken stomach: she's had stomach stapling.
House finds an old photo of Emmy showing she was fat, and then had the photos pulled from her records. Their conversation interrupts Cuddy, who is on the phone. House tells them to treat her like a fat girl and Kutner wonders if she had Type 2 diabetes. House tries to embarrass Cuddy on the phone but she refuses to flinch and takes the call outside. Kutner suggest sleep apnea that cut off the trachea and House insists it isn't apnea. He goes to where Foreman is conducting private tests with Thirteen. Thirteen is seemingly eager for the distraction and suggests side effects from the gastric bypass, leading to low potassium. House notes her potassium is fine but Kutner suggest that the bypass could have created a closed loop of intestines that caused bacteria, leading to sepo. House tells him to check her feces. Foreman points out they could have done the diagnosis anywhere but House says that it helped.
Taub explains the procedure and notes that Emmy is a hypocrite for not using the procedures she sells to her clients. She defends herself, saying she doesn't tell them to get surgery and she tried everything else she could but only gastric bypass surgery worked, and then she was happy. Taub wonders if she really is healthy and says that if she is, it's because she's pretty.
Wilson talks to Cuddy who defends her decision to share Cuddy's office. However, he accuses her of taking House's office just to be close to House. She orders him out.
As Kutner and Taub test Emmy's feces, Kutner says that Deedee, the person with the breast implants, is going to complain to the licensing board if he doesn't come up with an answer. House comes in, just missing the conversation, and tosses the sample in water to see if it floats. The lack of flotation means no sepo and the possibility of apnea. He tells them to watch Emmy overnight. As Kutner and Taub argue, they miss her getting up and going to the exercise room. She's running on a treadmill and says she feels great. She doesn't feel any pain from her broken ankle, or notice the bleeding. Taub pricks her with a syringe and she doesn't feel that either.
It's back to differential as Kutner and Taub confirm that the EEG eliminates the apnea diagnosis. They return to House's office only to discover that Cuddy has "accidentally" spilled hydrogen sulfide, stinking up the place. She leaves for the night and wishes them well as they have to stay there all night to deal with the patient. They move to the hallway but Foreman is called away. Thirteen tells him to wait and he notes she missed the last session. She says she'll be along, then suggest MS. House notes there are any number of possibilities involving her nerves and they need to run a NCV test to determine where the problem is.
Taub administers the NCV test and says he isn't interested in Emmy's rationalizations. She admits that if she was honest about the bypass surgery, no one would believe her but she wants to help people. She asks if he's done anything hypocritical and when she sees that her comment scores, says that he probably had good reasons too. She tries to lift her arm but is unable to do so, meaning the problem is with her muscles, not her nerves, and the NCV test is unnecessary.
Foreman goes to the waiting room but Thirteen isn't there.
Kutner and Taub are in the elevator discussing the case while a woman with tattoos and piercing stands behind them. She tells them she's going to see House and she's been e-mailing with him about her breast implants. Now she's losing her hair. They quickly close the elevator doors before House sees her and get her to the ER. Taub figures she has a staph infection from the piercings and tattoos. They go back to see House, who wonders why they took so long. Kutner suggests that House give up the office but he goes in and smashes Cuddy's new toilet. He then suggests chelation treatment for whatever toxins Emmy may have.
Thirteen arrives home to find Foreman waiting for her. He admits that she thought she was becoming self-destructive again, but only confirmed that she's been following all of his instructions. He asks why she can't show up for appointments and she says that she came down but there was another patient, Janice, in the waiting room. She doesn't want a visual reminder of what she'll eventually be going through. Foreman tells her either to show up or not to show up at all. As he goes, Thirteen remembers back to when she was a child when her father said her mother was leaving but Thirteen refused to leave her room.
The team meets on the stairs for a new differential once the chelation doesn't work. When Taub wonders why they're not meeting in House's office, he notes that Cuddy responded to his action by taking out all of the furniture. He's also interested that Thirteen is leaning away from Foreman. Foreman insists everything is fine and suggests Austrian's syndrome from alcoholism. House notes that Emmy doesn't drink and the tox screen didn't show alcohol anyway. First Kutner and then Taub get a page and both claim the call isn't important. Taub suggests Guillain-Barre, which leads from muscle weakness to total paralysis. House orders plasmapheresis treatment.
Taub and Kutner finally respond to their page and discover that Deedee is uncontrollably singing. Cameron tells them to bring in House because she must have a rare brain disorder. When she notes that Deedee is bleeding from the ears, she tells them to get House.
Taub explains to Emmy that she has Guillain-Barre and refuses to let her take a wheelchair when she's still strong enough to walk.
Kutner meets with Cameron and Chase in the cafeteria and tries to get some input. He finally comes up with a bilary tumor causing pareneoplasic syndrome and Chase agrees. He also agrees to test for it… as long as Kutner pays him 25% of his website earnings.
House is planning out his strategy to get back at Cuddy by replacing her toilet with a bidet. Wilson points out that the renovations will take longer, meaning Cuddy will be in House's office longer. He tells House to just ask Cuddy out.
Emmy starts hallucinating, believing her patients have come to visit and sit on her now that they know she's lying to them. House goes to his office, now empty of furniture, for a new differential given the new symptoms. Thirteen leaves for her appointment, suggesting it's CNS lymphoma. Taub suggests a prion disease but House notes if that's the case there's not much they can do. House orders a brain biopsy but Cuddy overrides him, suggesting they test for CNS lymphoma non-invasively first. He orders Kutner and Taub to run the non-invasive tests and then confronts her, saying she's overriding him because she has the hots for him. She accuses him of having the hots for him. She says that they're supposed to kiss now, but he points out they've already done that. Instead he grabs her breast. She admits she's an idiot for being surprised and walks off.
Thirteen arrives at the waiting room and sees Janice. Foreman says he can't reschedule and Thirteen might as well get to know her. As Thirteen looks at Janice, she remembers being in her bedroom as a child and watching her father take away her father. She then goes over and meets with Janice.
Taub has eliminated CNS lymphoma and Emmy asks to stop by the cafeteria for chocolate cake. He tells her not to give up and she wonders what they're hoping for. He admits that prion disease is next on the list and that it's bad. She says she might as well have a piece of cake and he agrees.
Later, Taub goes to House's office and tells him that Emmy tested negative for CNS lymphoma. He notices that the furniture has been returned. House asks Taub about his affair and if he was happy during it. Taub admits that superficially he was but deep down he was miserable. House notes he wasn't miserable, because he rationalized getting something for giving something. Taub, bemused, goes to get Cuddy's permission for the brain biopsy. House interrupts him, saying he'll do it himself. They go to Emmy's room and find her exercising.
With the new "symptom," it's back to differential and House doesn't believe someone could get better. Taub says the last thing he did was administer a MRI and then they went to the cafeteria for chocolate cake. House notes he's an idiot and takes a chocolate cake to Emmy. She's feeling worse again and serves her a piece of cake. House explains that she has hereditary coproporphyria which causes a lack of a vital enzyme to the liver. The treatment is a high-carb diet and sugar. Once they reverse the bypass surgery and she fattens up, she'll be fine. Emmy wonders if there's anything else they can try and Taub says there's a drug that manages the symptoms. She agrees to the drugs and refuses the surgery. House understands that she's rather be pretty than healthy.
Taub admits to Kutner that he's disappointed that Emmy is just as superficial as most other people. They go to see Deedee and a nurse informs them that she died and was moved before they could be reached.
Cuddy returns to her newly renovated office with Wilson, talking about how House isn't capable of intimacy. She sees her desk and realizes it's not the desk she ordered, but her desk from med school that she had in storage. She thinks about it and realizes who put it in there.
Thirteen admits to Foreman that she lied to him: Janice reminds Thirteen of her past, not her present. She admits that she wanted her mother to die after she lost her facilities in the last stages of Huntington's and yelled constantly at her. She never said goodbye to her mother, who died with Thirteen hating her. Foreman hugs her.
Kutner and Taub go to the morgue and Kutner berates himself for not taking more time. House arrives and says he's going to kill them, accusing them of being frauds and idiots who got a woman killed. He says that Deedee could have been treated and then wonders if it's not too late. He climbs up on her and applies CPR, and she comes back to life. Kutner and Taub jump back in terror… and House and Deedee burst out laughing. House set the whole thing up, and hired Deedee for two days to pretend she was the client. Kutner offers to take the website down, but House says to keep it up in return for 50% of the profits. As they go to work, Deedee points out that House still has three hours left.
Cuddy goes to House's office to thank him… and see him with Deedee. She turns around and leaves





