I'm as cynical as the next guy, scratch that, more cynical, but that last scene made me sad. She shouldn't have expected any different, but she looked so disappointed.
They say that a series goes down hill when the lead couple finally get together because all the sexual tension is gone, etc, etc. I think that's just a cop out. I'd like to see the writers take on the challenge of House and Cuddy as a couple. I think they NEED to take on the challenge. We're not surprised when the person who looks sick isn't the one who is sick in the opening, we're not surprised when the diagnosis is wrong. Nothing much in the show happens that we aren't expecting. Do I know how they could make House and Cuddy work? No, and that's why they need to do it.