House

At a fashion show of teen models, one of the models, Alex, confronts the director Austin back stage and complains of nausea. He blows it off and Alex's father Martin persuades her to go on after giving her some anti-anxiety pills. She reluctantly takes them then goes on to the runway but starts to sway then attacks another model before collapsing.

House wakes up to find his leg with even more excruciating pain than usual. He gets to the hospital where Wilson suggests the leg might be healing and House should go into rehab. House refuses but quickly takes on his newest case and even sees his patient right away when he hears the description "teenage supermodel." House suspects alcohol and the father reveals he gave her a valium. The tox screen shows heroin and valium and they go into differential diagnosis although House has more problems with his leg. They put her into a coma to pump her with drugs to rapid-detox her while Foreman talks to the father and warns the process is dangerous. The father agrees to the treatment as Alex starts to suffer from apparent withdrawal pains. Later she flatlines and the nurses are forced to resuscitate her.

House shows up the next day and Martin confronts her and withdraws her consent, insisting on a slow detox. House informs him they're committed and there's nothing they can do but continue. House then deals with a clinic patient who is suffering from sympathetic labor pains from his wife while Alex wakes up from the coma. She begins to repeat herself, suffering from short-term amnesia and some kind of brain injury, possibly from House's suggested treatment. House points out the flatline wasn't long enough for brain injury and suggests post-traumatic syndrome because Martin is abusing her. He suggests a MRI to show that her brain is normal and his diagnosis is correct.

Cuddy finds out House is out sick due to his leg pain and must deal with the man with the sympathetic labor pains, who refuses to talk to her. Finally he reveals that his breast are enlarging – Cuddy gives the guy House's personal page number. Foreman questions House on whether his pain is affecting his judgment and House reluctantly concedes the point. Then he confronts Martin directly, much to Foreman's exasperation. During the MRI, Alex starts to convulse. House calls Martin on how he "promotes" his daughter by describing her sexually and warns if Martin loves his daughter he has to be honest so they can diagnosis any psychological problems. Martin admits it happened – once. House tells the staff but the MRI shows elevated proteins in her CSF, which disprove all their theories.

House asserts they can't report sexual abuse due to doctor-patient confidentiality, much to Cameron's dissatisfaction. House orders a brain biopsy then goes to House for help. Foreman goes to Alex to let her know what they're doing next, overriding Martin. They proceed with the biopsy while Cameron goes to Cuddy with her gripes. Wilson administers a MRI while Cuddy confronts him about covering up the evidence of child abuse. She orders House to cooperate or she'll fire him.

While the staff debate the ethics, Wilson concludes the MRI shows no improvement and suggests Stacy's absence is the cause of House's various symptoms. The brain biopsy come back negative and House wonders if a tumor is responsible and causing antibodies to attack her brain. House comes up with a new "test" – he pinches the tube to cut off the IV drip and cut off the convulsions. Unfortunately that proves she has cancer.

House goes to Cuddy to ask for a favor – a shot of morphine into his spine to deal with the pain. House reluctantly reveals that there is massive deterioration of the thigh muscle tissue.

Alex goes into the MRI under Wilson's care but he concludes there's no cancer. Wilson is more concerned about what House is taking, but House ignores him and goes back into differential diagnosis. House concludes that Alex is subconsciously faking it and they give her a new IV of saline only. A social worker is meeting with Alex then points out there is no evidence and both parties deny it. Cameron confronts Alex who reveals she seduced Martin after getting him drunk, and he's not the first person she's slept with. Then Alex goes into convulsions.

Meanwhile House meets with George and his pregnant wife – they're both suffering labor pains and George's body is filled with estrogen. From that he concludes that Alex is…male. Alex has cancer…on her left testicle, and she's a male-psuedo hermaphrodite and immune to testosterone. Alex and her father clearly have some problems with the news.

House gives Cuddy an update on the case and then asks for another morphine shot – she concludes his solving the case is linked to the pain. Then Cuddy reveals she gave him a fake injection – a placebo. Later, while House plays the piano he considers his Vicodin and tries to go without it, but eventually gives in.