House

At a speed chess match, Nate is playing against an opponent and taunts him with his inevitable victory. Nate wins the game but when his opponent offers him congratulations, he hits him with a clock and then beats him bloody before collapsing from head pains.

After differential diagnosis and an initial conclusion of cluster headaches leading to Nate's aggressive personality, Chase snubs Foreman about giving him a recommendation for his upcoming job application, and tends to Nick treating him for the headaches. Nate's mom is relieved that the treatments might alter her son's obnoxious personality… for the better.

The next day Chase reports the treatments aren't working and Foreman complains to House that someone canceled his interview behind his back. Foreman tells House to either admit he wants him to stay or let him go, but House claims it wasn't him. He the goes to Cuddy and accuses her of sabotaging Foreman's interview but she denies it. He then asks her for hallucinogenic mushrooms to treat Nate and she reluctantly agrees. Nate's mother Enid agrees as well and Nate goes through hallucinations and exposes himself, where Cameron notices he has undersized testes, and they suspect a brain tumor. Enid agrees to it but Nate argues against it, and Nate blacks out from jaundice as his liver shuts down.

It's back to differential diagnosis and House suggests they stuff him full of meat (as Nate has been recently gone to a vegetarian diet) and test Nate once his ammonia levels spike. Foreman goes to Cuddy who offers to double his salary and set him up with his own diagnostic group. Foreman refuses and Cuddy admits she sabotaged his interview… then doesn't, to get him to admit he's not sure if House did it. Meanwhile, Chase finally blows up at Nate and tells him to eat the meat, and has him restrained if he doesn't go along. Nate reluctantly agrees.

Cuddy goes to Wilson and accuses him of sabotaging Foreman's interview. Wilson admits that he wants Foreman to go so House will realize he has limits and can't get everything he wants. She thinks he's lying and points out that whoever sabotaged Foreman's interview made sure he was leaving.

House meets with a man at a clinic who is sunburned and has white spots. House figures out the man's son put coins on him while the guy was sleeping. The tests on Nate prove negative and House orders him to fast to test his blood sugar levels. Nate goes into another rage and urinates blood on the floor.

In differential diagnosis they determine the bloody urine is from kidney failure. Foreman takes off for another job interview then later gives Nate a sedative so he can take a blood sample in peace, despite Enid's complaints. Wilson goes to Cameron and accuses her of sabotaging Foreman's interview, claiming Cuddy plans to fire him. Cameron quickly figures out he's lying about being fired and he figures she sabotaged the interview. Cameron claims she doesn't care about House and Wilson doesn't believe her.

Cameron then runs the tests with Chase and she accuses Chase of sabotaging the interview, just because he doesn't like Foreman. He denies it then makes his weekly advance toward her. They then discover a partial deficiency indicating a degenerative disease, Kelley-Seegmiller, but Cameron argues Nate isn't displaying sufficient aggressiveness. House suggests they speed up the degeneracy by applying more stress, while Chase gets the mother out of the way.

House wheels in a chess board to Nate's room and gives him an adrenaline shot. The game begins and they go back and forth until Nate gets House in what he claims is an untenable position, but then has a seizure. House considers the chessboard and talks to Foreman about his interview and who he provided as references. House eliminates the personality problems under the assumption Nate is just a jerk and orders a new bone marrow treatment for what he believes is amyloidosis. Foreman takes a nerve sample for a biopsy while Nate notes he sucks at treating him.

The new tests prove negative and foreman suspects an infection. House still believes it's an amyloid build-up. When Foreman gives in, House notes that Foreman still trusts House more then his own judgment. That night Chase confronts House and accuses him of sabotaging the interview, figuring House is playing everyone against each other. House admits it and doesn't think it'd do any good for him to admit he wants Foreman to stay. House realizes they forgot to take into account one symptom and determines Nate can't bend his thumb because his bones have formed abnormally. House concludes he has hemochromatosis: Nate's body has absorbed iron from food, and it's built up in his joints. He orders regular dialysis for the rest of Nate's life… and points out that he would have won their chess game and Nate was bluffing.

House goes to see Foreman… but tells him to run the tests for amyloidosis again without saying that he's figured out what's wrong with Nate.