At a banquet, best-selling author Timothy Moore is called upon by his publisher Elaine to give a speech to kick off his book tour. His editor Nick Greenwald goads him on and then tells him his book won't sell. Nick doesn't understand why he's saying what he's saying continues to tell everyone exactly what he thinks and then has a nosebleed and collapses.
House arrives at the meeting room and the team informs him about Nick's case and the fact he has frontal lobe diinhibition. House orders a nasal insertion to check Nick's nasal cavity for cancer. Kutner and Taub go to see him, and his wife and daughter Marika are already there. When Marika doesn't respond to them, Audrey explains that her daughter has an auditory processing problem. Nick starts to insult everyone and his wife leaves in irritation.
House invites Wilson to a monster truck show but Wilson says he can't go. Wilson finally tells him he hates monster trucks and has just put up with going to humor House. Kutner reports that they found no sign of brain damage but House insists that there's something wrong and orders more tests.
Cuddy gets a page to check on Nick, who describes her sexually. House sent the page and notes he did it for Cuddy's benefit. Meanwhile, Foreman discusses Nick's comments about Thirteen and she isn't thrilled with being judged sexually. As they monitor Nick, they ask him about his voting record and he tells them he doesn't vote. They spot a dark bit on his brain stem and as Thirteen leaves, Foreman considers her butt.
Taub is discussing his nose with Kutner as they eat, and discuss the social contract of people lying to each other. House sits with Wilson and wonders why it's so important he be nice. Wilson finally admits he's playing racquetball with Taub, but didn't want to tell House because he thought he'd be rubbing it in that House can't play.
Foreman checks on Nick as his kidneys start to shut down. They put him on dialysis and go over the case, and House asks Taub about his game with Wilson. He's clearly skeptical about what they're doing. House has them test the daughter for inherited neurological conditions and punishes Taub by ordering him to do all the blood draws. He tells Taub he'll keep harassing him until he tells him the truth.
Kutner tests Marika with hot and cold sensors and Audrey worries if what Nick's saying is what he's always felt. Marika starts to scream in pain from the treatment and confesses she didn't say anything because she wanted to help her father. Meanwhile, Taub runs the blood tests and Nick asks him to keep Hadley away. He admits that while he has such thoughts, he has never done anything to hurt his wife. Nick notices that Taub feels guilty when he mentions cheating on one's wife, and Taub hastily leaves.
House pages Taub to come to the morgue so he can test his racquetball skills. Taub agrees after House threatens to fire him, and gives his report on Nick. The blood tests show that Nick's glaucoma level is normal, meaning he's negative for diabetes. He finally admits he isn't playing racquetball with Wilson and claims that he wanted Wilson to owe him a favor. House doesn't believe him and tells him to have Kutner run more tests. Nick refuses once he discovers that Marika was hurt. He claims that Marika doesn't have an auditory problem and insists that she daydreams and she's below average. Audrey tries to keep him from talking but Marika runs away. Nick suffers from a sudden fever as his lungs fill with fluid.
Back in differential, House orders Kutner to keep testing Nick and checking on his background. He tells Taub to do something else. A little later, Taub visits Wilson to ask him to lunch, but quickly admits House sent him as a double agent. As Kutner does the tests, Nick asks Audrey to leave, saying he doesn't know what he'll say next. As Kutner leaves, he sees House outside of Wilson's office. He gives his report and notes that Audrey has brought home a dog recently. Kutner suspects that the dog is responsible for a bacterial infection and House agrees and orders doxycycline treatment.
Taub comes out and reveals he managed to print out Wilson's e-mails. Wilson has been in contact with a Dr. Gonzalez at a hospital for a consult in Manhattan. Gonzalez deals with depression in cancer patients and Taub wonders if Wilson is depressed. House doesn't believe it.
Nick starts to recover thanks to the treatment but Foreman and Kutner warn that the damage caused by the infection won't go away. Surgery near the brain stem is extremely dangerous but Nick is less than thrilled.
House is waiting for Wilson as he walks into the lobby. House figures he's worried about something and reveals he knows about Gonzalez. He then figures Wilson is worried about something because he left his coat behind. Wilson snaps at him, saying he just wants a part of his life that House leaves alone.
House returns to his office to find Nick waiting for him. Nick is angry that they can't cure him and insists that House authorize the operation so he can have his old life back. House goes to Chase and asks him to convince his boss to do the surgery. Chase wants to know why House cares and House explains that Nick is concerned that he'll drive everyone away with his obnoxious mannerisms and assessments. Chase agrees to do what he can.
Chase and his boss proceed with the surgery as House watches. Wilson enters the galley and says he overreacted. House figures he's upset because he lost someone. He checked the name Gonzalez and found a nurse with the name in the psych ward. House reveals that he's learned Wilson's brother Daniel is in treatment there. Wilson tells his friend that Daniel is on anti-psychotics and should be in condition to talk later that night. He explains that he didn't tell House because they don't have the normal social contract: House wouldn't reassure him the way anyone else would. House admits it's true… but offers to go with him.
Foreman and Taub check on Nick in post-op. He's fine from the surgery but he's still suffering from disinhibition. He starts to insult Audrey again as his temperature drops and she demands answers. His heart stops as Audrey backs away in shock and anger.
Back in differential, the team is unable to contact House. Foreman eliminates cancer and orders a full body scan, but Taub points out House wouldn't do it and it won't do any good. Foreman goes ahead with it anyway. In New York, Wilson and House wait to see Daniel and Wilson talks about how he spotted his brother once but could never find him. House knows the team is trying to get hold of him but ignores the call.
The team goes over the scans and they try to pinpoint the problem before Nick's temperature drops to fatal levels. They find a cyst and prepare to treat. Meanwhile, House concludes that Wilson went outside with his coat to punish himself. Wilson admits that he was at med school and didn't have the time to talk to Daniel. One night he hung up on his brother and the next day Daniel ran away. House figures Wilson developed his people-pleasing skills as an overreaction, but Daniel overreacted as well. House realizes what is wrong with Nick and calls his team to tell them that he has a fibroma and their treatments have caused Nick's body to overact to it, causing all of his problems. House turns to discover that Wilson has already gone to see his brother.
Later, Nick checks out and apologizes to Taub. Audrey comes in and tells Nick that she's been offered a better position. Nick compliments her and wonders if Marika is okay. A nervous Audrey assures him that their daughter has moved on.
As House leaves, he runs into Wilson, who says he'll be meeting with his brother again and would like House to meet him. Wilson explains that he and his brother are just strangers and it was anti-climactic. House wonders if Wilson is okay with their relationship and their honesty, and Wilson admits it's a relief to have someone he doesn't ever have to worry about lying to.





