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At the end of the episode, the police officer pulls House over, and tells him his pupils are dilated. The officer alludes to this as being an indication of being under the influence. Throughout the show, Dr. House has used opiate medications for pain, namely Vicodin. Vicodin does not dilate the pupils. Opiate medications, in general, constrict the pupils. Dilated pupils would be indicative of other drug misuse, such as benzodiazapenes, but not Vicodin or any other painkiller. Also, it's night so House's pupils would be dilated regardless.
House diagnoses Ali with coccidioidomycosis in Cuddy's office. However, whilst Coccidioides immitis would cause cold-like symptoms, it would not cause lack of inhibition like House suggests.
When they are strapping Adam to the scanner, the hands that strap his head belong to a woman, and have perfectly manicured fingernails. When the shot pans out, the person standing near Adam's head is a man.
When the kid is laying down about to be scanned, you can see his hair is perfectly arranged, after that his hair is all messy for no apparent reason.
The age of consent in New Jersey is 16, making the issue raised moot from a legal standpoint.
Trivia: The wall clock in the MRI procedure room has the words Stoia Tucker on it. This is the name of the pharmaceutical company that provides anti-tuberculosis medications that Dr. Sebastian Charles uses to treat TB patients in Africa in "TB or Not TB", episode #26 (episode 4 of season 2).
Powell's colonoscopy is of a clean colon. In order for his colon to be that clean they would need to prep him overnight, which they did not do.
When House and Foreman are arguing about giving Ezra the fatal dose of morphine, the level that the plunger is pushed into keeps changing from fully withdrawn to two-thirds in as the camera angle cuts back and forth between them.
Cameron suggests they make an antibody to a protein on the surface of the "alien" cells so that they can tag them for the PET scan. No problem there, monoclonal antibodies are widely used for purposes such as these ... but generating, screening, purifying and labeling a new antibody is a process that takes around six months at the very least. The show seems to suggest this only took days at most.
When House asks Cameron to put her diagnosis in the form of a metaphor she talks about making nerves 'light up like lightbulbs'. This is a simile not a metaphor.
When he goes into the machine that looks for the tagged proteins, Clancy goes in head-first. However, the computer shows Clancy's results feet-first.
Although House is pain-free and able to walk without the assistance of his cane, he should still be walking with a limp due to his lack of thigh muscle.
The prescription that House writes for himself at the end of the episode is for a nonexistent medicine. House writes for "Vicodin ES 5/500," which is actually two different strengths of the same med. Standard-strength Vicodin is "5/500" (5 milligrams hydrocodone, 500 milligrams acetaminophen), and Vicodin E(xtra) S(trength) is 7.5/750. A doctor would write for either "Vicodin 5/500" OR "Vicodin ES," not the combination of the two. Also, given the progression of House's dependence and level of pain, it is not unlikely that he would have moved on to an even stronger strength Vicodin (like double-strength "Norco") or oxycodone.
When House splits his stitches and collapses to the floor outside the patient's hospital room, a red fake blood bag falls out on the floor to his side just before the scene fades.
There are several events that contradict previous events from prior episode and even the beginning of the episode, as far as characters knowing things only House could know, characters saying different things then they said originally, etc. Given the nature of most of the episode, these can be accounted for by the fact that...well, House at least knows them.
House's name tag establishes his birth-month is in June. But in "The Socratic Method," his birthday was much later in the year when Cameron wished him a happy birthday.
Near the end, House claims that, unusually, none of the staff ever challenged his epiphanies. But at the 11:40 mark, House has the epiphany of trying a lumbar puncture and Foreman challenges it, saying there's too much pressure. Chase argues House's case, House backs it, and Foreman accepts, but Foreman typically protests and then caves anyway. This makes House's later statement incorrect.
Trivia: In this episode, watching the restaurant scene, we can see that both Cuddy and Wilson are left-handed.
It's clear at several points (primarily due to the stiffness of the neck) that the baby is a prop doll.
Instead of doing a white matter brain biopsy, why didn't House just biopsy the brain tissue that was associated with causing the euphoria? If the disease had attacked that part of the brain then there might still be remnants of it there.
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Medical, quirky characters, fighting doctors, drug addiction, hospital backdrop