Jeremiah is a personal favorite of mine. It has one of the best stories I have seen, truly unique. They do a good job at developing the story throughout the life of the show. There are a few parts where your watching and thinking, "What is this, why would they put this in the show?". But I mean that is to be expected.
As for the rest of the show, as opposed to the story, it isn't great, I mean it's hard to tell if it's bad acting or the scripts just weren't that well written (I suspect the latter), but the story behind the show makes up for it for me.
A must see for anybody that truly appreciates a unique and unconventional story.