At the beginning of this episode when Diego proposes to Jesse, both Jesse and Diego are wearing different shirts from the first season's cliffhanger.
Diego: I was stupid enough to believe that you would appreciate, like, a big grand gesture and that you would find it romantic and be swept off your feet.
Jesse: Yeah, well maybe next time you do a grand gesture you should call first.
Diego: That is not a grand gesture, that is a planned gesture.
Jesse: I took on too much, all right? It is too hard for me. I'm just in—I'm in over my head, alright? I'm not Superwoman, okay? I'm Rather-Incapable Girl.
Jesse: I don't work here anymore. Take your pee to the mean man.
Linda: You still want to be a nurse?
Jesse: Yeah, of course. You know, it's still hard, and gross stuff happens, but there's enough cool stuff in between all the gross stuff to make it okay, you know?
Linda: Wow, that's how my mom described sex.
Kurt: You're a distracted person; my time is precious.
Kurt: You were late today, that took up my precious time. You're in nursing school. I'm a nurse. You'll ask me questions. Avoiding you will take up my precious time. You have a family life. You'll want to show me pictures. Pretending to be interested will take up my precious time.
The series was completely retooled between seasons, with Jesse's father and brothers disappearing and the featured workplace becoming a hospital.