The series concludes with Christina Ross returning home and Jessie heading to Los Angeles for a role in a movie. But when the kids realize they still need Jessie, they follow her to Hollywood.
Luke and Ravi attend an Astronomer's Club meeting in Central Park; Jessie prepares for an audition; Emma is determined to sneak out to a late night party; and Zuri and Bertram do a marathon of their favorite show.
The Ross kids plan on going trick-or-treating with Stuart while Jessie attends a masquerade ball in the park and meets someone.
Mrs. Kipling becomes a celebrity and it puts a strain on her relationship with Ravi. Meanwhile, Bertram preps Emma for an audition; and Zuri tries to become more independent.
Ravi and Emma feel their identities have been stolen when Luke becomes the brain of the family and Zuri the trendy fashionista.
Bertram's new toupee that he bought for his band's big performance goes missing, so Jessie interrogates each of the kids in the hopes of finding it.
The Ross family pull out all the stops to secure dates to a school dance. Meanwhile, Jessie helps Bertram prepare for his first solo at the Metropolitan Opera. The Vamps perform.
Part 3 of 3. Jessie abruptly ends the Ross family vacation when the kids constantly fight. The next morning they find the yacht floating in the middle of the sea with no captain or crew in sight.
Part 2 of 3. A tour guide on an Italian island tells the Ross family a story about Jessie's necklace and how its curse brings anyone who wears it bad luck in love.
Part 1 of 3. While vacationing aboard their yacht, the Ross family find a girl stranded in the ocean and invite her aboard. Meanwhile, Bertram stays home and babysits Mrs. Kipling, who has separation anxiety from Ravi.
Bertram quits and goes to work for Mrs. Chesterfield. Meanwhile, the Ross family hires a new butler who takes his job very seriously.
Jessie tries to teach Emma how to drive. Meanwhile, Ravi and Luke accidentally break one of Zuri's games, which leads them to a standoff.
Jessie tries to help Ravi make friends by taking him to a MENSA meeting in the park where they meet new a friend who may be too good to be true. Meanwhile, Luke drags Bertram to a sports collectibles show and Jessie meets a new guy.
When the power goes out and the kids can't use their electronic devices, Jessie suggests a game of Capture the Flag as an opportunity for family bonding.
Chris Paul of the Los Angeles Clippers tutors Ravi in basketball, Jessie is forced work with Hudson for a class exercise, and Zuri keeps 'borrowing' Emma's clothes.
Jessie doesn't know how to deal with Emma when her unexpected bad behavior gets her suspended from school. Meanwhile, Luke teaches Zuri in preparation for her karate belt test.
Despondent over yet another failed audition, Jessie decides to go back to college. Meanwhile, Zuri brings a baby giraffe home from Africa and Emma comes up with a prank to get back at Luke for all his pranks.
When the tax department freezes Morgan and Christina Ross' assets, Jessie and the children band together to get through the rough times.
When Jessie's stepsister Darla comes to visit, Jessie decides to tell her that she went through with her wedding to Brooks and enlists Tony's help to pull off the lie. Meanwhile, Luke shaves for the first time and when Bertram helps, he makes things much worse.
Bertram misleads the kids into thinking that Jessie has gone to Africa to be with Brooks, so they all set out to find her and bring her home.