The show is based on the character Joey (Matt LeBlanc from Friends), his sister and her son. Joey leaves New York, moves to Hollywood and becomes a full time actor. The show is basically a sequel to Friends without the best characters.
Joey was bearable at best in Friends, making him the lead of a show is a recipie for disaster. The humour is dim and it was rare that it even raised a slight chuckle from me. The funniest part of this show was probably the fact that NBC actually let it run for 46 episodes. Complete waste of time.