John says the killer is methodical, but he doesn't kill in any discernible pattern. The fifth donor (Dan Perry) was killed first, then the fourth donor, then the sixth donor (Zeke Pepperfield). If he was working backward from his own position as #7, it should have been Pepperfield, then Perry, then the fourth donor.
John sees in shades of grey, which is only one type of total color blindness called cerebral achromatopsia and caused by brain injury, due to once having had memories of colour. The other is monochromatic vision, congenital achromatopsia, and John should not have referenced the number of achromatopes when wondering who his parents were. (lysdexia, RL Doe apparently)
John mistakenly identifies the blue and black Harley as a 2002 "Intruder. Also, "805 c.c." is incorrect - it should read as 80.5 Cubic Inches, or approximately 1300 Cubic Centimeters.
So...what happened to the last donor, William Sullivan? They never determine who he is is, or take any steps in this episode to determine that's who John really is. We're not even clearly told if he's still alive or if Sherman killed him. Hopefully they'll follow up on this.
When Frank and John analyze the killer's apartment they figure out the killer is going back to Vitrochoice where it all began. Frank says, "The source?" and John says, "Vitrochoice, the donor bank." Then they look at the evidence for a bit, and then John figures out again that he's going back to Vitrochance where it all began.
After Digger makes the last shot William Forsythe says what sure sounds like, "Thanks for doing all the heavy lifting, Dom." (some thought he says "Doe" but Forsythe sure seems to pronounce it with a short-o/'ah' sound rather than a long-o - in other words, 'dahm' rather than 'doh'.)
At the end when the people are playing chess in the park, the closest group of guys, the guy on the left hits the timer *then* moves his piece and *THEN* tries to hit the timer *AGAIN*??? Chess timers are a see-saw device and you hit the timer *after* your move.
Regarding "the source" comment:
Frank and John read the diary that says "The cycle must be broken. I will put them out of their misery. Starting at the source." This is the reference to him starting at VitroChoice and getting all of the donor information to track them down, as well as setting up the chronological time sequence. They then follow the sequence and jump to the end (Wesley) and try to figure out where it will *end*. That's when John paraphrases the earlier quote "I will put them out of their misery... at the source" "He's headed back to VitroChoice... where it all began." Essentially the killer is going back to the beginning... again.
At the beginning of the episode, John, Hayes, and Hayes' son are watching football. But despite Seattle having an NFL team, the three of them are watching a CFL game on Canadian station TSN. Further, the team was 3rd and long to make a 1st down while playing 3 points up on their opponent well before half-time. Anyone who knows anything about the CFL knows that they use 3 downs instead of 4 - thus this would have most certainly have been a punting situation. Yet John claims that this offensive coordinator uses the play he predicted 77% (or so) of the time. You would never see that play occur in that situation. Next, despite Saskatchewan having possession, the clock advanced 7 minutes (in less than 1 minute real time), and Toronto magically scored a point (single) in the meantime. (Some thought there might have been some kind of compressed time-jump, and that one team could have scored a rogue one-pointer in the time period shown.)
Wesley: Isn't John Doe the name they give to unidentified people? What are you, like, a spy or something?
John: Ha. I'm not a spy.
Wesley: Well, then, what's your real name?
John: That is my real name.
Wesley: So, your parents are Mr. and Mrs. Doe, and they named you John?
John: Something like that.
Frank: Don't you know anything about kids?
John: Yeah, the average ten-year old male grows 54 point...
Frank: Oh man...
Karen: Excuse you – did you just smell me?
Elvis Braithwaite: Emperor penguins use their sense of smell to determine their mates?
Karen: Neat. (moves away)
John: I know everything about fatherhood. But nothing about being a dad.
Frank: Now that is the smartest thing I've ever heard you say.
Lt. Avery: It's never a simple gunshot wound with you, is it, Doe?
Nurse: (to John) Congratulations. You seem to know all there is to know about...semen. I'm sure you won't have any trouble providing some.
Music: 1) "Bus Stop" - Arlo, 2) "Don't Ask Me" - OK Go, 3) "You're Here To Stay" - Unknown
A short scene in this episode is just a re-used scene from the second episode "Blood Lines", when John is in the sperm bank and he gets the fingerprint, it shows a close up of the fingerprint, and this closeup is actually the same closeup of the fingerprint John got at the start of "Blood Lines".
a.k.a. "About a Boy"
Frank: Oh great. So we got the Cy Sperling of Sperm? Not just the founder, he's also a client?
Cy Sperling was the president of "Hair Club for Men." His catch phrase was: "And, by the way, I'm not only the Hair Club president, but I'm also a client."
Frank: Looks like Little Man Tate is still following you around.
Refers to a movie about a single parent bringing up a boy genius of a son, Fred.