John Goodman previously played a hotshot exterminator in the film Arachnophobia (1990), as the protagonist.
Tagline: "Hib-hob-gibble-boo-boo!" -Dale
Ladybird's 14th birthday is celebrated in this episode.
Hank: No! Snakes are awful pets! They're like sticks that breathe!
(Hank and Dale are descending into Arlen's sewers to catch the snake)
Dale: These public sewers are labyrinthian! Since Tommy and Rollo never actually trained me, we could get lost down there, become one of the mysterious sewer people. Over time, my memories of the English language will disappear, and I will be forced to invent my own - hib-hob-gibble-boo-boo! Skeeble!
Hank: The sewers are completely safe! Joe Jack: Let's hear you say that while sitting on a toilet.
(Bobby's snake Josh starts moving towards Luanne)
Luanne: It's coming to kill me! It knows I'm a Christian!
The alternative title to this episode was "Snakes in a Suburb."
Title: SerPUNt is an allusion to the scene in the 1951 animated film production of Lewis Carroll's Alice In Wonderland. Alice has sampled the mushroom and grown tall enough to protrude through a tree canopy disturbing a nesting bird who repeatedly cries out Serpent! in a distinct way (SerPUNt!) in panic while Alice tries to calm her and deny being a serpent.
This episode is an allusion to the popular Harry Potter saga by author J.K. Rowling. Specifically book two of the series Harry Potter and the Chamber of Secrets, in which protagonist Harry Potter must explore the Hogwarts' sewer and plumbing systems to find and vanquish the basilisk (a mythical representation of a snake).