Luke Perry, Chris "Ludacris" Bridges, Van Hunt. Comedy bits included Conan being mentioned on "Jeopardy!," "The Evil Puppy," "Celebrity Survey," and the Saga of LaBamba.
At the top of the show, Conan mentioned that he was watching "Jeopardy!" the night before and noticed that the popular "In the Year 2000" sketch from the show was mentioned in a question, although none of the three contestants answered correctly.
Introduced as one of the new characters for 2006 in episode #2170, "The Evil Puppy" returns after the date of 06/06/06 as a sign of pure evil for the date associated with satan.
In this edition of "Celebrity Survey," Conan published information he learned from a recent "survey" he "sent" to several celebrities. His survey was mailed to such celebrities as Barry Bonds, Britney Spears, Arnold Schwarzenegger, President George W. Bush, Richie Sambora, Scott Baio, Laura Bush, Kevin Federline and Paris Hilton.
After the first commercial break, Conan mentions that band members, Mark Pender and LaBamba were touring with Bruce Springsteen and were unable to play for the show. He then begins to speak of of their one-night replacements, namely Clark Gaton, LaBamba's fill-in. Conan calls Gaton "easily the best trombone player I've ever heard," causing LaBamba to walk out of the studio, an act which Conan slowly regrets. The band then breaks out into a special rendition of "She's Gone" by Hall & Oats, which Conan helps to provide the lyrics for. A video of LaBamba after he left is shown slowly sliding into despair, drinking heavily, selling his clothes, and trying to eat his trombone. After a pause in the musical number, LaBamba returns and they then sing "He's Back."