Watching a series end to end non-stop changes your perspective on the direction it took. I did not miss an episode of Lie to Me when it was on the air and was truly disappointed when it was cancelled. Re-watching the series on Netlix helped me pin point it's demise however. I still enjoyed the show, but in the 3rd season the personality of some key characters changed, mainly Gillian. The cast did not seem to gel the same way they did in the previous seasons. And replacing Reynolds with a dirty cop (Wallowski) did not help either.
At the same time it was an excellent show and worth the time spent watching!