We can assume that Connor and Dr. Ewing have some sort of past together, possibly a relationship.
GOOF: A patient's wife, who is in seclusion, talks to him by cell phone. Cell phones can't be used in hospitals. They have the same frequency as many machines, such as ones used for dialysis. It causes malfunctions.
When asked if Carlos has any relatives, Holly neglects to mention he has a long-lost brother and mother living in Hawaii. Possible explanation: Since Carlos doesn't like to share his family history, he could have asked Holly not to speak of it.
Holly also neglected to mention that Carlos has a daughter that he gave up for adoption, when she was asked if Carlos has any relatives. Possible explanation: As before, Carlos likely told Holly not to share information about his family, since he is uncomfortable discussing it.
Bubonic, pneumonic, and septacemic plague are not three strains of the disease- they are three different manifestations of the same bacillus, in the lymph glands, the lungs, and the blood. There are different strains of the bacillus, but these are more scientifically interesting than anything else; all could have the same effect.
GOOF: Around 13m 10s in the show, you see where Garcia is laying on the bed, and they remove the mask to intubate him, next scene you see they intubate him, but when the camera switches he has the mask back on, 1 sec later again you then see where they still intubate him.
This week's disease: Smallpox
Smallpox is caused by the variola virus and causes raised bumps on the face and body. It is a serious, contagious and sometimes fatal disease but it has been eradicated by a worldwide vaccination program. Once it was eliminated, vaccinations were no longer necessary.
The last case of Smallpox in the US was in 1949, but the latest worldwide case was in Somalia in 1977.
The fact that the body had been frozen should have been obvious to any competent pathologist immediately. There are other factual anomalies about the body.
1) Although the actual time line is not clear, the body probably had been exposed for several days. In fact, a body exposed by a glacier does not pop to the surface like an ice cube. Rather, it is gradually exposed to the elements a little bit at a time sometimes over several years. But there is no mention or appearance of decomposition.
2) Stephen said that the hole in the body appeared to be from a .22. Most weapons from 170-200 years ago were fairly large caliber, often as big as .75 caliber (3/4 inch). Also, the bullet extracted was way to large for a .22 and had the appearance of a lead ball, not a modern bullet.
3) The skin on the body was remarkable undamaged for having slid down the side of a mountain and floated down a mountain stream.
GOOF: Frank states that 170 years after John Doe and his family had died, their descendants fell ill to smallpox; however, Natalie had stated that John Doe had died over 200 years ago.
GOOF: Connor tells the team to where masks and gloves when entering the room of the smallpox patients, however Natalie and Miles are seen in the room without protection on.
This week's disease: Coccidioidomycosis
A fungus which is found in the soil of semi-arid areas. Disturbance of the soil makes the fungus airborne which when inhaled causes fever, cough, headaches and rashes. The percentage of people who become infected is low but can be extremely serious.
The disease is also known by a number of names - Posadas disease, San Joaquin fever, San Joaquin Valley disease, San Joaquin Valley Fever, and Valley Fever.
GOOF: When the sick volleyball player is about to have a piece of her lung taken for examination the rash on her face and neck seems to have disappeared.
As we are being shown the contaminated sand being removed by specially suited personnel and told that the spores can travel hundreds of miles our two NIH staff are standing a few yards away without even a face mask.
This week's disease: Necrotizing Fasciitus
A flesh-eating bacteria which destroys soft-tissue. Usually enters through an opening in the skin, e.g. cuts, surgery. It is usually easily killed with antibiotics but some strains are life-threatening.
This week's disease: Aplastic Anaemia
Aplastic Anaemia is a rare disease where the bone marrow fails to produce blood cells which affects the immune system, blood clotting and the carrying of oxygen in the blood.
A person can be born genetically predisposed but the most common cause of Aplastic Anaemia is through exposure to drugs or environmental toxins, Benzine being the most common cause.
Goof: During the team-wide discussion about where the disease cames from, Connor refers to authorities in the Asian Bird Flu calling in the "Calvary". He means "cavalry".
Location: If the town square of Deering, Virginia looks familiar, that is hardly surprising. The location is a backlot at Universal Studios, known as "Courthouse Square". Its most famous use was as Hill Valley in the Back To The Future films.
The set was previously known as "Mockingbird Square" due to its appearance in "To Kill A Mockingbird", but was renamed after use in "Back To The Future". It has also appeared in many other productions, including "Weird Scence", "Gremlins", "Dr Quinn, Medicine Woman" and "The Ghost Whisperer".
This week's disease: Anthrax
Anthrax is found in animals such as cattle, sheep etc. Humans can be affected if exposed to infected animals.
There are three types of Anthrax: cutaneous (skin), inhalation and gastro-intestinal (consumption). Anthrax by inhalation is usually fatal.
Anthrax has been used as a bio-warfare agent.
When MacCabe and his team visit the Nigerian butcher shop, a anti-fly/pest zapping light can be seen in the background. This is a no-no in many butcher shops due to health codes and regulations.
In reality, the CDC (Centers for Disease Control) would handle a case involving Anthrax outbreak since they are outfitted to containing outbreaks, not the NIH (National Institution of Health) since they are mainly used for investigative purposes where there isn't a threat to the public.
This week's disease: Multiple Sclerosis
An unpredictable disease of the central nervous system which disrupts communication between the brain and other parts of the body.