The parasitic catfish that swims into Murderface's urethra is based on a real fish called the candiru.
This is a parody of Sepultura recording an album with the Xavante people of the Xingu River, only it appears to be around the Orinoco instead.
This episode marks the second appearance of Cardinal Ravenwood in season two.
Silenoz and ICS Vortex from band Dimmu Borgir lend their voices for this episode.
One of the pilots was called Hellhammer. Hellhammer is a 1980's Swedish heavy metal band.
When Nathan is telling the story about his grandmother, Pickles mentions that the story is "like a Cannibal Corpse song".
The title and Dethklok's attempt to pull their boat over a mountain alludes to the Werner Herzog film Fitzcarraldo in which the character (and the actors) attempt to pull a river boat over the mountain.