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Oliver is in charge of rehabilitating Wallace and Clyde since he believes they still have good left in them. Meanwhile, Kaz tries to give himself superpowers with Skylar's help.
When superhero Spark, a tough-as-nails teenage girl, meets Kaz at Mighty Med, they go out on a date. But Spark becomes crazy jealous of anyone Kaz talks to, so he fakes his death in hopes she'll go away, but when Spark learns the truth, it breaks her heart.
Oliver cares for a sack of valuable eggs when a pregnant superhero is admitted to the ER, and Kaz helps him hide his pregnant state at school.
In an attempt to recruit new superheroes, Kaz holds superhero tryouts. Meanwhile, Oliver takes Skylar to a dance tournament to try to cheer her up when she’s not allowed to compete in the superhero tryouts.
Oliver, Skylar, Alan and Gus work on a school project together, and Kaz is left alone at Mighty Med while a rare and dangerous alien bug is on the loose.
A man from the future reveals himself to be an older Kaz, who seeks to eliminate someone who may turn out to be an evil villain. To the boys' shock, it could be Oliver! Meanwhile, Skylar learns she's the most hated among the superheroes at Mighty Med and seeks to redeem herself among the group.moreless
Evil Skylar realizes her powers are greater than the Annihilator's and no longer wants to take orders from him, leading Oliver and Kaz into a desperate situation in order to save her. Meanwhile, at the comic book store, Jordan suspects superheroes are real and seeks to expose Techton as one.
Kaz and Oliver travels to Caldera, Skylar's home planet, to find Hapax the Elder. There, they try to convince him to come back to Earth and defeat the Annihilator, but he needs to see their bravery first. Meanwhile, Horace struggles to keep Alan away from Optimo when he visits Mighty Med.moreless
Kaz and Oliver try to prevent Skylar from discovering that they know she is evil, so she won't kill them. But the situation gets complicated when Skylar asks Oliver to the school dance. Meanwhile, Alan finds himself in the middle of Gus and Jordan's prank war against each other.
Kaz and Oliver suspect there's a mole working with the Annihilator and Agent Blaylock returns to question a few suspects, including Alan.
Oliver and Kaz plan to infiltrate the Annihilator's lair to take his collection of superpowers and restore them to the superheroes, but a still evil Skylar thwarts their efforts. Meanwhile, Alan and some of the heroes attend a Halloween party at the high school figuring the students will think they're ordinary people in costume.moreless
Kaz and Oliver are trapped in the ER by an evil Skylar and the Annihilator. The two villains plan to take over the hospital, and eventually, the world. Meanwhile, Jordan and Gus run the comic book store in Wallace and Clyde's absence.