Well, tecnhically, sure. It "could" come back, if the sales were phenomenal. And I'm rather sure they weren't. Clone High, on DVD was actually fairly successful, and it wasn't officially available in the USA, and it hasn't come back yet. Family Guy has a huge amount of 'word of mouth' sales and just pop culture infussion. Mission Hill had the first animated male-male kiss on television and it was glossed over.
I would love to have the original creators and writers come back and continue on the story, but the sales aren't all that great to warrant bringing the cast all together again. *Speculation* (I'm assuming they weren't all that great) And its a dirty shame.
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