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The Indianapolis Colts welcome in the Cincinnati Bengals which will be a battle of high-powered offenses.
The Chicago Bears take their 10-2 record to St. Louis to battle with the Marc Bulger and the Rams.
Two teams fighting for the playoffs meetin in Philadelphia when the Panters take on the Eagles.
Mike Holmgren and his Seattle Seahawks will face off against his former team, the Green Bay Packers at Qwest Field in Seattle.
In an AFC vs NFC match-up, the NY Giants travel to Florida to take on the Jacksonville Jaguars.
In a match-up of NFC South teams, Tampa Bay takes on Carolina in Charlotte.
This week the Oakland Raiders play in Seattle against the defending NFC Champion Seahawks.
Tom Brady leads his 5-1 Patriots to Minnesota to take on the 4-2 Vikings.
This week we get one of the most anticipated matchups of the 2006-07 season with the New York Giants against the Dallas Cowboys.
The undefeated Bears travel west to the new University of Phoenix Stadium to take on the Arizona Cardinals.
The Ravens take their undefeated record to Denver to take on the Jake Plummer and Broncos.
Brett Favre leads the 1-2 Packers into Lincoln Financial Field to take on Donovan McNabb's 2-1 Eagles.
In a battle of unbeaten NFC South teams, the Michael Vick & the Atlanta Falcons take on Reggie Bush and the New Orleans Saints.
In a battle of 1-0 teams, the Steelers go to Alltel Stadium to do battle with the Jacksonville Jaguars and Byron Leftwich.
Game two of the Monday Night doubleheader features AFC West rivals the Oakland Raiders and San Diego Chargers.
After 36 seasons on ABC, Monday Night Football moves to ESPN and debuts with a doubleheader. The opener has the Minnesota Vikings traveling to FedEx Field in Landover, Maryland to face the Washington Redskins.