The comparison to Monty Python is inevitable (both Bob Odenkirk and David Cross have acknowledged their debt to their predecessor in interviews), but make no mistake: "Mr. Show with Bob & David" is refreshingly original and brilliantly funny. There have been so many hilarious moments on the show that it would be impossible for me to name a particular favorite. The sketches are so finely crafted that even when the jokes fall flat (which is extremely rare), they're still quite engrossing ("Coupon: The Movie" is an example). I've been watching the show faithfully since its second season and each new episode only leaves me wanting more. The show's strong ensemble cast featuring John Ennis, Jill Talley, Tom Kenny and especially Jay Johnston are part of what makes the show work so well.
Being on HBO, they're pretty much able to do what they please, but while there is plenty of profanity (not an issue for me at all), they are in no way reliant upon cussing for laughs. In fact, one of the more memorable sketches involved a take-off of "Goodfellas" being edited for television in which the cuss words were replaced with such phrases as "mother-father" and "Chinese dentist".
HBO deserves to be praised for recognizing the talent of Bob & David and keeping the show on the air in spite of its small - albeit fiercely loyal - number of viewers.
The next time HBO airs a "Mr. Show" marathon, don't just watch it, tape it!