Song: Helen Reddy's Muppet version of "You and Me Against the World". Includes some photo clips with Johnny Fiama, his mother and Sal in various funny situations.
Running gag: - Clifford and Rizzo the Rat shocked stares
- Sal having accidents after finishing the letters he wrote to reunite Jonnhy Fiama and his mother.
Johhny Fiama's mother: (tries to read Sal's letter from Johnny, but fails) But I can't read this monkey scratching!
Sal: I'll try doing it for you (stares at his letter)
Waldorf: You know, this show reminds me of a glass of expensive brandy.
Statler: Why's that?
Waldorf: Because it's old and it makes my head hurt.
Muppet guy at studio: Hey! You look just like Big Mean Carl!
Big Mean Mom: He's my son! I'm Kyla, the Big Mean Mom!
Muppet guy at studio: Nice to meet you! (extends a hand)
Big Mean Mom: Nice to eat you, too! (eats muppet guy)
Statler: You know...
Statler: This show reminds me of a twenty-five-cent cigar.
Waldorf: Oh yeah? Why is that?
Statler: Because it's cheap and it stinks!
Darci: (interview) When I sing my songs, I'm the most sensitive... and vulnerable. (recording shows Darci singing to Clifford and Rizzo) I hate men! I hate men!
Clifford: (stares, shocked)
Darci: I bet they'll die! Death to a man! (looks at Rizzo) I hate rats, too...
Rizzo: (covers in fear)
Darci: (to Clifford) So? Whatcha think?
(Johnny Fiama is waiting for the elevator)
Sal: Hey, Johnny, Johnny, Johnny!
Sal: I just met this girl from the studio next door, and we're going out tonight... and get this, get this, she's got a sister!
Johnny: (stares at Sal No, no! Sal, forget it! (Sal complaints) I've been out in your monkey dates before and I've spent the entire dinner getting bugs out of my hair!
Supposedly, the last episode of Muppets Tonight.
The official episode guide at Henson.com referred to the episode as "Johnny Fiamma Leaves Home," indicative of the back-and-forthing on the spelling of the character's name during the series.