Budi Sabri's condition is based on the real-life case of the Indonesian Dede Kosawa, also known as Treeman. Dede's treatment also includes taking Vitamin A as seen in the show.
Matt mentioned that Sean hit him once. This hapenned in the season 3 episode "Derek, Alex and Gary".
Goof: Just before Christian realizes his implant is loose, his partner's bra strap falls off and on of her shoulder over the next couple of scenes.
In the flashback to Carrie May getting arrested, the name of the school is J. Scott Middle School. The director of this episode is John Scott.
When Matt and Raj are discussing their sexual history, Raj mentions the encounter he had with a man (which took place in "Gene Shelly".
While Christian is being treated near the beginning of this episode, he is watching "Ellen". Ellen DeGeneres is married to Portia de Rossi, who plays Olivia during this season.
It's revealed that the events from the future, shown in the season 4 episode "Conor McNamara, 2026", were just a dream Sean had.
Just before she is confronted by Colleen, Eden is talking on the phone to Chaz. This is Chaz Darling, her friend (played by Jai Rodriguez), who featured in an earlier episode of the same name.
It's revealed that Freddie's middle name is Christopher.
The case being shown in the episode of Hearts & Scalpels at the beginning of the episode- the clitoral reconstruction- is a reference to the Season 2 episode Manya Mabika.
Although Julia got the first, and only, slice of the fruit cake which Eden cut, it was clearly an inner cut of the cake, even though we witness Eden cutting off the outside piece of it for Julia, which is baked all the way around.
Carol mentions the Hedda Grubman Plastic Surgery Fund during the initial consultation with Christian and Sean. In the Season 4 episode "Conor McNamara", it was revealed that Mrs, Grubman had left all her money to this fund for people who wanted surgery but couldn't afford it.
It's revealed that nurse Linda's last name is Klein. Which means, all this time, the actress have been playing herself.
Tiffany Pollard (a.k.a. 'New York') appears in this episode- the filming was shown on her self-titled VH1 reality dating show.
Goof: Sean and Christian go into the recovery room to chack on Dawn, and she "tells" them about the stool samples, she has the words "Bird Flu?" written on her chalkboard. As they leave the room, she puts the chalkboard down and you can see that it says "Who do I have to screw around here to get a smoothie?", a phrase she had written down in a previous scene.
Eden Lord is 18 years old. (The actress portraying her, AnnaLynne McCord, was born in 1987 and was 20 at the time.)
In Aiden's first onscreen appearance, he tells Freddy "A musical episode? How gay is that? Come on, this is the kind of desperate schlock you don't do til your fifth season!"
This is a subtle dig at other TV programs, who after entering their fifth season (or after shooting 100 episodes), tend to run out of ideas and create more outlandish storylines and episodes to keep the audience's attention. It also appears to be a tounge-in-cheek reference to Nip/Tuck (a show which has always had outrageous characters and storylines) entering its own fifth season with this episode.
Christian marks Carly's portrait with lipstick to highlight areas for surgery. He did the same with Kimber in the pilot episode and Abby Mays in the Season 3 episode of the same name- although he marked their bodies with lipstick instead.
The deal that Christian and Sean strike with Hearts And Scalpels- producer credits and the occasional line- is a similar deal to one that Linda Klein (Nip/Tuck's medical consultant who plays Nurse Linda in the show) has with Nip/Tuck.
During the scene where they're touring through the studio on a golf cart, it clearly sounds like Julian McMahon was speaking with his native Australian accent.